山东中医杂志2025，Vol.44Issue(5)：539-544,6.DOI:10.16295/j.cnki.0257-358x.2025.05.010
健脾通络方联合化疗治疗大肠癌术后气虚血瘀型患者临床研究
Clinical Study on Jianpi Tongluo Prescription(健脾通络方)Combined with Chemotherapy for Treating Patients with Qi Deficiency and Blood Stasis Syndrome After Colorectal Cancer Surgery
摘要
Abstract
Objective:To evaluate the clinical efficacy and safety of the Jianpi Tongluo Prescription(健脾通络方)combined with the mFOLFOX6 chemotherapy regimen in treating patients with qi deficiency and blood stasis syndrome after colorectal cancer surgery.Methods:A total of 60 patients with qi deficiency and blood stasis syndrome after colorectal cancer surgery were divided into a control group and an observation group according to the random number table method,with 30 cases in each group.The control group was given chemotherapy with the mFOLFOX6 regimen,and the observation group was additionally given oral administration of the Jianpi Tongluo Prescription on this basis.Both groups took 14 days as one treatment cycle and received continuous treatment for 4 cycles.The traditional Chinese medicine(TCM)syndromes scores,Karnofsky performance status(KPS)score,and chemotherapy adverse reactions of the two groups of patients were compared,and the therapeutic effects on TCM syndromes in the two groups were evaluated.Results:After treatment,the main symptom score,secondary symptom score,and total score of TCM syndromes in both groups decreased significantly compared with those before treatment(P＜0.001).Moreover,the main symptom score,secondary symptom score,and total score of TCM syndromes in the observation group were all lower than those in the control group(P＜0.05,or P＜0.01,or P＜0.001).Additionally,the KPS score of patients in the observation group increased significantly compared with that before treatment(P＜0.001)and was higher than that of patients in the control group(P＜0.001).During the treatment,the degrees of leukopenia,nausea and vomiting,and diarrhea in the observation group were milder than those in the control group(P＜0.05).After treatment,the total effective rate of TCM syndromes in the observation group was higher than that in the control group.The difference of the curative efficacy on TCM syndromes between the two groups was statistically significant(P＜0.001).Conclusions:Compared with the simple mFOLFOX6 chemotherapy regimen,the Jianpi Tongluo Prescription combined with the mFOLFOX6 chemotherapy regimen can significantly relieve the clinical symptoms of patients with qi deficiency and blood stasis syndrome after colorectal cancer surgery,improve their functional status,reduce chemotherapy adverse reactions,and enhance the curative efficacy.关键词
健脾通络方/mFOLFOX6化疗方案/大肠癌/气虚血瘀/中医证候评分/卡诺夫凯斯计分/化疗不良反应Key words
Jianpi Tongluo Prescription/mFOLFOX6 chemotherapy regimen/colorectal cancer/qi deficiency and blood stasis/traditional Chinese medicine syndromes scores/Karnofsky performance status score/chemo-therapy adverse reactions分类
中医学引用本文复制引用
崔文文,张洁,于边芳,管忠安..健脾通络方联合化疗治疗大肠癌术后气虚血瘀型患者临床研究[J].山东中医杂志,2025,44(5):539-544,6.基金项目
山东省自然科学基金项目(编号:ZR2021MH399) （编号:ZR2021MH399）
国家中医优势专科建设项目(编号:YWC2023ZYYSY0002) （编号:YWC2023ZYYSY0002）
齐鲁中医药优势专科集群建设项目(编号:YWC2022ZKJQ0003) （编号:YWC2022ZKJQ0003）
山东省中医药科技发展计划项目(编号:2019-0070) （编号:2019-0070）
