世界科学技术-中医药现代化2025，Vol.27Issue(4)：909-917,9.DOI:10.11842/wst.20240331001
类器官在肺癌领域研究进展及应用探讨
Research Progress and Application of Organoids in Lung Cancer
摘要
Abstract
Organoids,as a three-dimensional structural model that has been rapidly developed and widely concerned in recent years,enable the key functions and microenvironment of internal organs to be simulated in the real world,and closely reflect the physiological and pathological characteristics of the natural occurrence and metastasis of tumors,providing a new platform for disease modeling,drug research and precision medicine.This paper briefly summarizes the limitations and development prospects of organoid models,analyzes the current construction and development of organoid models of lung cancer and its applicability compared with traditional models under the holistic concept of traditional Chinese medicine and the basic theory of syndrome differentiation and treatment,and discusses the application of organoid technology in the basic research of lung cancer treatment.The advantages in screening anti-tumor Chinese medicine and drug resistance research and precision medicine provide new ideas for realizing innovative breakthroughs in traditional Chinese medicine research combined with modern science and technology.关键词
类器官/肺癌/中医药/精准医疗Key words
Organoid model/lung cancer/Traditional Chinese Medicine/Precision medicine分类
医药卫生引用本文复制引用
张玉新,王琳璇,张颖,李娜娜,马祯慧,李梦珂,李洪霖..类器官在肺癌领域研究进展及应用探讨[J].世界科学技术-中医药现代化,2025,27(4):909-917,9.基金项目
国家自然科学基金委员会青年科学基金项目(81804057):温阳散结汤通过TGF-β信号通路调控肿瘤相关巨噬细胞与调节性T细胞平衡抑制肺癌免疫逃逸的研究,负责人:李洪霖 （81804057）
河南省中医管理局河南省中医药科学研究专项课题(2022ZY2018):温阳散结方及其有效成分通过铁死亡途径调控肺腺癌上皮间质转化的机制研究,负责人:李洪霖. （2022ZY2018）
