世界科学技术-中医药现代化2025，Vol.27Issue(4)：931-938,8.DOI:10.11842/wst.20240524001
肺络构效失衡与特发性肺纤维化生物力学特性机制相关性探微
Discussion on the Correlation Between the Structure-Activity Imbalance of Lung Collaterals and the Biomechanical Properties of Idiopathic Pulmonary Fibrosis
摘要
Abstract
Guided by the pathogenesis of"structure-activity imbalance of lung collaterals",this paper proposes that structure-activity imbalance of lung collaterals is the initial factor of idiopathic pulmonary fibrosis(IPF)and elucidates the pathogenesis of abnormal changes in biomechanical properties of IPF.It is postulated that the changes of biomechanical properties of lung tissue are closely related to the injury of lung qi collaterals,the abnormal mechanical stress are closely related to the injury of lung blood collaterals,and the biomechanical response of intrapulmonary resident cells is closely related to the structure-activity imbalance of lung collaterals,which ultimately leading to abnormal increase in lung tissue stiffness and progressive scarring formation in lung tissue.Integrating traditional pathogenesis concepts with microscopic pathological changes,and the in-depth exploration of the correlation between the structure-activity imbalance of lung collaterals and the biomechanical properties of IPF can provide direction for exploring IPF medical-engineering cross research,which are of great significance for enriching the syndrome and treatment system of lung collateral diseases.关键词
特发性肺纤维化/肺络构效/生物力学/细胞外基质/发病机制Key words
Idiopathic pulmonary fibrosis/Structure-activity of lung collaterals/Biomechanics/Extracellular matrix/Pathogenesis分类
医药卫生引用本文复制引用
刘勇明,吕晓东,梁元钰,庞立健,臧凝子,王靖宇,邹吉宇,王佳然,赵仲雪,郑钰..肺络构效失衡与特发性肺纤维化生物力学特性机制相关性探微[J].世界科学技术-中医药现代化,2025,27(4):931-938,8.基金项目
国家自然科学基金委员会青年科学基金项目(82204993):参龙煎剂调控miR-487b/NRP1-HIF2α-EPCR轴改善特发性肺纤维化血小板活化效应机制研究,负责人:刘勇明 （82204993）
国家自然科学基金委员会面上项目(82274440):益气养阴活血通络法调控周细胞-内皮细胞Ang/Tie2信号恢复内皮生态位改善血管通透性治疗IPF机制研究,负责人:吕晓东 （82274440）
辽宁省自然科学基金委员会联合基金(面上资助计划项目)(2023-MSLH-183):益气养阴活血通络法调控ADAMTS-13/vWF/GPIb-IX-V信号轴介导"血小板活化-细胞外基质硬化"干预特发性肺纤维化生物力学特性机制研究,负责人:刘勇明. （面上资助计划项目）
