世界科学技术-中医药现代化2025，Vol.27Issue(4)：950-961,12.DOI:10.11842/wst.20240619004
龙胆苦苷作用于疾病的分子机制
Molecular Mechanism of Gentiopicroside on Diseases
摘要
Abstract
Gentiopicroside(GPS)is the main active ingredient extracted from Gentiaceae.It has anti-inflammatory,antioxidant,analgesic,anti-fibrosis,inhibition of tumor cell proliferation and improvement of glucose and lipid metabolism.Gentiaceae shows a wide range of application prospects in the treatment of diabetes,liver diseases,bone and joint diseases and other diseases.This paper reviewed the pharmacokinetics of gentiopicrin,including its pharmacokinetic properties in different animal models,and its mechanism and targets in the treatment of diabetes mellitus and its complications,liver injury,bone and joint diseases.Studies have shown that gentiopictin exerts its therapeutic effects by regulating various signaling pathways,such as PI3K/AKT,FOXO1,PPAR-γ,NF-κB,etc.Although the current research has made some progress,there are still limitations,such as most studies focused on animal models and in vitro experiments,lack of high-quality clinical evidence-based trials support.Future studies should further explore the new targets and signal transduction pathways of gentiopicroside,improve its bioavailability,and strengthen the research of traditional Chinese medicine compounds,so as to give full play to the advantages of holistic treatment of traditional Chinese medicine.关键词
龙胆苦苷/机制研究/药代动力学/糖尿病/肝脏疾病/骨与关节疾病Key words
Gentiopicroside/Mechanism research/Pharmacokinetics/Diabetes mellitus/Liver disease/Bone and joint diseases分类
医药卫生引用本文复制引用
李明秀,李青松,杨晓彤,杨锐峰,吴丽丽,刘铜华,秦灵灵..龙胆苦苷作用于疾病的分子机制[J].世界科学技术-中医药现代化,2025,27(4):950-961,12.基金项目
教育部高等学校学科创新引智计划项目(B20055):中医药防治糖尿病及其并发症学科创新引智基地负责人:刘铜华 （B20055）
科技部重点研发计划(2021YFE0106300):南非传统草药治疗糖尿病研究,负责人:刘铜华. （2021YFE0106300）
