现代检验医学杂志2025，Vol.40Issue(3)：113-117,5.DOI:10.3969/j.issn.1671-7414.2025.03.021
帕金森氏病患者血清外泌体α-突触核蛋白、血清脂钙素-2水平表达及与疾病严重程度的关系
Expression of Serum Exosomal Alpha-Synuclein,Serum Lipocalcin-2 Levels and Their Relationship with Disease Severity in Patients with Parkinson's Disease
摘要
Abstract
Objective To investigate the expression of exosomal α-synuclein(α-syn),serum lipocalcitin-2(LCN-2)levels and the relationship with disease severity in Parkinson's disease(PD)patients.Methods 106 PD patients admitted to Yulin Hospital,the First Affiliated Hospital of Xi'an Jiaotong University,from June 2020 to June 2023 were selected.The PD patients were divided into the early group(n=31),the middle group(n=45)and the late group(n=30)according to their conditions,and 92 healthy volunteers who had outpatient medical checkups during the same period were selected as the control group.The exosome α-syn and serum LCN-2 levels were detected,and the differences in exosome α-syn and serum LCN-2 levels were compared in PD patients with different disease severity levels.Factors affecting the prevalence of PD and the value of exosomal α-syn and serum LCN-2 in diagnosing PD were analyzed.Results The levels of exosomal α-syn(3 086.23±359.46 pg/ml)and serum LCN-2(4.92±1.32ng/ml)in the PD group were higher than those in the control group(1 993.24±244.35 pg/ml,1.96±0.34 ng/ml),and the differences were statistically significant(t=24.636,20.909,all P<0.05).The levels of exosomal α-syn(3 312.72±53.46pg/ml)and serum LCN-2(5.76±0.28ng/ml)in the late-stage group were higher than those in the early-stage(2 843.65±65.29pg/ml,4.02±0.32ng/ml)and the middle-stage group(3 102.35±105.48pg/ml,4.98±0.41ng/ml),and the differences were statistically significant(t=9.092～30.644,all P<0.05).Family history of PD,high level of exosomal α-syn and high level of LCN-2 were the risk factors for the development of PD(Wald χ2=8.121,7.002,4.805,all P<0.05).The AUC(95%CI)of diagnosing PD with serum LCN-2 in combination with exosome α-syn was higher than that of exosome α-syn,while serum LCN-2 alone was used for diagnosis(Z=4.869,5.103,all P<0.05).Conclusion Serum exosomal α-syn and serum LCN-2 levels are significantly higher in PD patients,which can be associated with the exacerbation of PD,and combined exosomal α-syn and serum LCN-2 can assess the risk of developing PD.关键词
帕金森氏病/外泌体/α-突触核蛋白/脂钙素-2/疾病严重程度Key words
Parkinson's disease/exosome/α-synuclein/lipocalcitin-2/disease severity分类
临床医学引用本文复制引用
郑雪姣,薛玉英,加艳,李田..帕金森氏病患者血清外泌体α-突触核蛋白、血清脂钙素-2水平表达及与疾病严重程度的关系[J].现代检验医学杂志,2025,40(3):113-117,5.基金项目
陕西省卫生健康科研项目(2020E012). （2020E012）
