现代检验医学杂志2025，Vol.40Issue(3)：123-128,6.DOI:10.3969/j.issn.1671-7414.2025.03.023
急性ST段抬高型心肌梗死患者血清IRGM,Syndecan-1水平表达对PCI术后预后的影响
Effect of Serum IRGM,Syndecan-1 Level Expression on Prognosis after PCI in Patients with Acute ST-segment Elevation Myocardial Infarction
摘要
Abstract
Objective To investigate the effect of serum expression of immune-related guanosine triphosphatase M(IRGM)and Syndecan-1levels in patients with acute ST-segment elevation myocardial infarction(ASTEMI)on the prognosis after percutaneous coronary intervention(PCI).Methods 135 patients with ASTEMI admitted to Suzhou Jiulong Hospital of Shanghai Jiaotong University School of Medicine from January 2021 to January 2023(ASTEMI group)were selected and divided into the poor prognosis group(n=37)and the good prognosis group(n=98)after PCI treatment for 3 months,and 65 physically examined and healthy people(control group)were also selected during the same period.The enzyme-linked immunosorbent assay(ELISA)was used to detect serum IRGM,Syndecan-1 levels,Logistic regression was used to analyze the influencing factors of poor prognosis after PCI in ASTEMI patients,and receiver operating characteristic(ROC)curves were plotted to evaluate the predictive value of serum IRGM,Syndecan-1 levels on poor prognosis after PCI in ASTEMI patients.Results Compared with the control group,serum IRGM(6.17±2.50 ng/ml vs 2.59±0.94 ng/ml),Syndecan-1(420.97±123.65 ng/ml vs 278.89±43.06 ng/ml)levels were higher in the ASTEMI group,and the differences were statistically significant(t=14.628,11.932,all P<0.001).During a three-month follow-up,the incidence of poor prognosis after PCI in 135 patients with ASTEMI was 27.41%(37/135).The age,proportion of KILLIP grade≥II,Gensini score,white blood cell count,LDL-C,IRGM and Syndecan-1 levels in the poor prognosis group were higher than those in the good prognosis group,and the LVEF scores was lower than those in the good prognosis group,and the differences were statistically significant(χ2/t/Z=2.119～8.042,all P<0.05).Independent risk factors for poor prognosis after PCI in patients with ASTEMI were KILLIP classification≥II,high Gensini score,high IRGM,high Syndecan-1,and high LVEF were the independent protective factors(Wald χ2=4.225～11.413,all P<0.05).The AUC(95%CI)of serum IRGM combined with Syndecan-1 level in predicting poor prognosis in patients with ASTEMI after PCI was larger than that of IRGM,and Syndecan-1 alone predictsed poor prognosis,and the differences were statistically significant(Z=3.400,2.905,all P<0.05).Conclusion High serum IRGM,Syndecan-1 level is an independent risk factor for poor prognosis after PCI in pa-tients with ASTEMI,and the combination of serum IRGM,Syndecan-1 level has a high predictive value for it.关键词
急性ST段抬高型心肌梗死/免疫相关鸟苷三磷酸酶M蛋白/多配体蛋白聚糖-1/经皮冠状动脉介入治疗Key words
acute ST-segment elevation myocardial infarction/immune related guanosine triphosphate M protein/syndecan-1/percutaneous coronary intervention分类
临床医学引用本文复制引用
杨海燕,翁洁瑶,钱怡琳,王瑾枫,张凯..急性ST段抬高型心肌梗死患者血清IRGM,Syndecan-1水平表达对PCI术后预后的影响[J].现代检验医学杂志,2025,40(3):123-128,6.基金项目
江苏省卫生健康委科研课题(BJ22017). （BJ22017）
