现代妇产科进展2025，Vol.34Issue(5)：357-361,5.DOI:10.13283/j.cnki.xdfckjz.2025.05.003
S100A8/A9 阻滞剂ABR25757 对大鼠子宫内膜异位病灶的作用效果
Effect of S100A8/A9 blocker ABR25757 on endometriosis in rats
摘要
Abstract
Objective:To investigate the effect of the specific blocker ABR25757 on endometriotic lesions by blocking the S100A8/A9 protein in a rat model.Methods:An endome-triosis(EMT)animal model was established via intraperitoneal injection and validated.One week after modeling,Group A received intraperitoneal injections of PBS at the same frequency,with the experiment ending after three weeks.Group B started ABR25757 at 5mg/kg intraper-itoneally once daily for three days from the second week,ending after three weeks.Group C be-gan ABR25757 at 5mg/kg intraperitoneally once daily for three days from the second week,ending after four weeks.Rat weight changes,lesion volume,and microvascular density(MVD)were compared among groups.VEGF and TGF-β expression levels were detected using immuno-histochemistry and Western blot.Results:The success rate of intraperitoneal injection modeling was 90.5％.Compared to Group A,lesion volumes in Groups B and C significantly decreased(P=0.032,P=0.019).MVD in Groups B and C was significantly lower than that in Group A(P=0.000,P=0.000),and MVD in Group C was significantly lower than that in Group B(P=0.000).Immunohistochemistry and Western blot showed that VEGF expression in Group B was significantly lower than that in Group A(P<0.05),and TGF-β expression in Groups B and C was significantly reduced compared to that in Group A(P<0.05).Conclusion:Intraperitone-al injection is an effective method for modeling endometriosis.ABR25757 has a certain inhibito-ry effect on endometriosis and may represent a new treatment approach for endometriosis.关键词
子宫内膜异位症/S100A8/S100A9Key words
Endometriosis/S100A8/S100A9分类
临床医学引用本文复制引用
张雯文,王丽茹,朱根海..S100A8/A9 阻滞剂ABR25757 对大鼠子宫内膜异位病灶的作用效果[J].现代妇产科进展,2025,34(5):357-361,5.基金项目
海南省科技专项资助(No:ZDYF2022SHFZ021) （No:ZDYF2022SHFZ021）
