无机材料学报2025，Vol.40Issue(4)：337-347,11.DOI:10.15541/jim20240431
基于微流控技术的纳米无机生物材料制备:原理及其研究进展
Microfluidic Technology Based Synthesis of Inorganic Nano-biomaterials:Principles and Progress
摘要
Abstract
Inorganic nanoparticles have demonstrated significant applications in biomedicine field,whose biomedical functions and physicochemical properties are greatly influenced by their size and morphology.However,it still remains challenging to achieve high batch-to-batch reproducibility in the synthesis of inorganic nanoparticles with traditional batch synthesis methods.Meanwhile,microfluidic technology offers an advanced strategy that provides high controllability and repeatability for the synthesis of inorganic nanoparticles.Additionally,it facilitates rapid mass and heat transfer,while offering the advantages of small reaction volumes and low energy consumption,rendering it an ideal approach for the synthesis of inorganic nano-biomaterials.This article reviews the research and application progress of microfluidic technology in preparation of inorganic nano-biomaterials.Firstly,flow regimes and principles of mixing in the microfluidic devices are introduced.Subsequently,structural features and fluid mixing efficiency of five widely studied and applied microfluidic devices are presented.Importantly,applications of these microfluidic devices in synthesis and surface modification of inorganic nanoparticles are comprehensively summarized.Finally,this article briefly outlines challenges and potential opportunities for future developments in microfluidic-based synthesis and application of inorganic nano-biomaterials.关键词
纳米颗粒/微流控/微反应器/无机生物材料/综述Key words
nanoparticle/microfluidics/microreactor/inorganic biomaterial/review分类
药学引用本文复制引用
田睿智,兰正义,殷杰,郝南京,陈航榕,马明..基于微流控技术的纳米无机生物材料制备:原理及其研究进展[J].无机材料学报,2025,40(4):337-347,11.基金项目
国家重点研发计划(2022YFB3706303) （2022YFB3706303）
国家自然科学基金(52472290,52072392) （52472290,52072392）
中国科学院青年创新促进会(2020255)National Key Research and Development Program of China(2022YFB3706303) （2020255）
National Natural Science Foundation of China(52472290,52072392) （52472290,52072392）
Youth Innovation Promotion Association CAS(2020255) （2020255）
