眼科新进展2025，Vol.45Issue(6)：463-467,5.DOI:10.13389/j.cnki.rao.2025.0081
成人与儿童视网膜血流灌注面积差异对比及其与眼轴长度的相关性分析
Comparison of retinal vascular perfusion area between adults and children and its correlation with axial length
摘要
Abstract
Objective To compare the blood flow perfusion area in different retinal vascular plexuses between adults and children using swept-source optical coherence tomography angiography(SS-OCTA)and explore the correlation of the retinal blood flow perfusion area with spherical equivalent(SE)and axial length(AL).Methods A total of 112 partici-pants,including 58 children(116 eyes,aged 8-13 years)and 54 adults(108 eyes,aged 18-30 years),were recruited from Eye Hospital,Wenzhou Medical University from December 2020 to December 2024.Based on SE,these children and adults were further divided into the emmetropia(-0.50＜SE ≤+0.50 D),low myopia(-3.00＜SE≤-0.50 D),and moderate myopia(-6.00＜SE≤-3.00 D)groups.SS-OCTA was used to acquire the perfusion area data across retinal vascular layers.The inner vascular network of the retina was subdivided into the peripapillary radial vascular network,su-perficial vascular plexus(SVP),middle vascular plexus(MVP),and deep vascular plexus(DVP).The blood flow perfu-sion areas across retinal vascular layers were compared between adults and children.Pearson correlation analysis was per-formed to assess the correlation of the blood flow perfusion areas across retinal vascular layers with AL and SE in adults and children,respectively.Results SE was negatively correlated with AL in both adults and children(r=-0.781 and-0.667,respectively;both P＜0.001).The total inner retinal perfusion area was negatively correlated with AL in both adults and children(r=-0.239 and-0.299,respectively;both P＜0.05).In children,the perfusion area in the peripapil-lary radial vascular network,SVP,and DVP was negatively correlated with AL(r=-0.443,-0.315,and-0.220,respec-tively;all P＜0.05).In adults,the perfusion area in SVP,MVP,and DVP was negatively correlated with AL(r=-0.243,-0.230,and-0.364,respectively;all P＜0.05).Adults with low/moderate myopia exhibited a significantly larger perfu-sion area in the peripapillary radial vascular network compared with children with corresponding myopia levels,and the differences were statistically significant(both P＜0.001).Conclusion There were significant differences in the perfu-sion area of the peripapillary radial vascular network between adult and pediatric myopic patients.AL showed the strongest correlations with the perfusion area of the peripapillary radial vascular network in adults and the perfusion area of DVP in children,respectively,suggesting distinct effects of retinal vascular layers at different stages of ocular growth.关键词
视网膜灌注面积/近视/眼轴长度/光学相干断层扫描血管成像技术Key words
retinal perfusion area/myopia/ocular axis length/optical coherence tomography angiography分类
临床医学引用本文复制引用
陶杰,王敏,朱秀影,罗玥,谢娟,李琴,游银银,陈琦,邹云春..成人与儿童视网膜血流灌注面积差异对比及其与眼轴长度的相关性分析[J].眼科新进展,2025,45(6):463-467,5.基金项目
国家自然科学基金青年基金项目(编号:82000930) （编号:82000930）
浙江省自然科学基金探索一般项目(编号:LY22H120009) （编号:LY22H120009）
四川省科技厅自然科学基金(编号:2022NSFSC0754) （编号:2022NSFSC0754）
