现代检验医学杂志2025，Vol.40Issue(3)：84-90,7.DOI:10.3969/j.issn.1671-7414.2025.03.016
2型糖尿病肾病患者血清lncRNA MEG3,lncRNA SOX2OT水平表达与肾功能及预后的相关性研究
Correlation between Serum lncRNA MEG3,lncRNA SOX2OT Level Expression and Renal Function and Prognosis in Patients with Type 2 Diabetic Nephropathy
摘要
Abstract
Objective To investigate the relationship between the serum levels of lncRNA mathematically expressed gene 3(lncRNA MEG3),lncRNA SRY-box transcription factor 2 overlapping transcript(lncRNA SOX2OT)and renal function and prognosis in patients with type 2 diabetic nephropathy(T2DN).Methods 205 patients with T2DN admitted to Shaanxi Provincial People's Hospital from January 2019 to January 2021(T2DN group)were selected,as well as 150 simple T2DM patients(T2DM group)and 150 healthy individuals(control group)during the same period.And the patients with T2DN were classified into the poor prognosis group(n=73)and the good prognosis group(n=132)according to the 3-year prognosis.Serum levels of lncRNA MEG3 and lncRNA SOX2OT were detected.Pearson analysis was used for correlation analysis;The influencing factors were analyzed using logistic regression,and the predictive value was evaluated using the subject's work characteristic curve.Results The serum lncRNA MEG3(2.20±0.32)in the T2DN group was higher than that in the T2DM group(1.49±0.20)and control group(1.00±0.06),and the lncRNA SOX2OT(0.50±0.11)was lower than that in the T2DM group(0.73±0.15)and control group(1.05±0.16),the differences were statistically significant(t=23.960,45.322;28.745,16.670,all P<0.01).The serum lncRNA MEG3 levels in T2DN patients were negatively correlated with estimated glomerular filtration rate(eGFR)and positively correlated with urinary albumin/creatinine ratio(UACR)levels(r=-0.532,0.485,all P<0.01)and the serum lncRNA SOX2OT level was positively correlated with eGFR and negatively correlated with UACR(r=0.421,-0.517,all P<0.01).The risk factors for poor prognosis in T2DN patients were chronic kidney disease stage 4,UACR and lncRNA MEG3(Wald χ2=6.360,6.678,16.652,all P＜0.05)while the protective factors were eGFR,lncRNA SOX2OT(Wald χ2=5.463,11.797,all P＜0.05).The AUC predicted by the combination of serum lncRNA MEG3 and lncRNA SOX2OT was larger than that predicted by lncRNA MEG3 and lncRNA SOX2OT predicts separately,and the differences were statistically significant(Z=3.841,3.337,all P<0.05).Conclusion Elevated serum lncRNA MEG3 levels and reduced lncRNA SOX2OT levels are associated with reduced renal function and poor prognosis in patients with T2DN,and the combination of the two tests has a high predictive value for poor prognosis in patients with T2DN.关键词
2型糖尿病肾病/长链非编码RNA母系表达基因3/长链非编码RNA SRY盒转录因子2重叠转录本/肾功能Key words
type 2 diabetic nephropathy/lncRNA maternally expressed gene 3/lncRNA SRY-box transcription factor 2 overlapping transcript/renal function分类
医药卫生引用本文复制引用
鲍楠,张蓬杰,朱燕亭,闻苗苗..2型糖尿病肾病患者血清lncRNA MEG3,lncRNA SOX2OT水平表达与肾功能及预后的相关性研究[J].现代检验医学杂志,2025,40(3):84-90,7.基金项目
陕西省自然科学基础研究计划项目(2021JQ-905). （2021JQ-905）
