肿瘤内微生物群与肺癌关系的研究进展OA北大核心
Research Progress on the Relationship between Intratumor Microbiota and Lung Cancer
肺癌的发病率和死亡率在全球癌症中居于首位.近年来,随着微生物检测技术的发展,肿瘤内微生物群逐渐成为肺癌研究领域的热点和前沿.研究发现存在于肿瘤内的微生物群可以通过多种方式影响肺癌的发生发展.此外,肿瘤内微生物群可以作为肺癌诊断和预后评估的潜在生物标志物,通过调节肺癌瘤内微生物群有望成为新型的肺癌治疗方式.本文将系统综述肿瘤内微生物群与肺癌相关的最新研究进展,总结肺癌瘤内微生物群的来源和特征,探讨其影响肺癌发生发展的机制,并展望其在肺癌诊断、治疗和预后中的应用前景.
Lung cancer has the highest incidence and mortality of any cancer in the world.In recent years,with the development of microbial detection technology,the intratumor microbiota has gradually become a hot spot and frontier in the field of lung cancer research.Studies have found that the microbiota present in tumors can influence the development of lung cancer in a variety of ways.In addition,the intratumor microbiota can be used as a potential biomarker for the diagnosis and prognosis assessment of lung cancer,and the regulation of the intratumor microbiota of lung cancer is expected to become a new type of lung cancer treatment.In this paper,we reviewed the latest research progress on the relationship between intratu-mor microbiota and lung cancer,summarized the origin and characteristics of intratumor microbiota,discussed the mechanism of its influence on the occurrence and development of lung cancer,and explored its potential applications in the diagnosis,treatment and prognosis of lung cancer.
朱杨彤;陈佳威;朱燕倩;吴林玉
310006 杭州,浙江中医药大学附属第一医院(浙江省中医院),浙江中医药大学第一临床医学院310006 杭州,浙江中医药大学附属第一医院(浙江省中医院),浙江中医药大学第一临床医学院310006 杭州,浙江中医药大学附属第一医院(浙江省中医院),浙江中医药大学第一临床医学院310006 杭州,浙江中医药大学附属第一医院(浙江省中医院),浙江中医药大学第一临床医学院
肺肿瘤瘤内微生物作用机制生物标志物
Lung neoplasmsIntratumor microbiotaMechanism of actionBiomarker
《中国肺癌杂志》 2025 (4)
304-308,5
本文受浙江省自然科学基金项目(No.LTGY23H180001)、浙江省卫生健康科技计划项目(No.2022KY230,No.2024KY132)和浙江中医药大学科研项目(No.2022FSYYZY08)资助 This paper was supported by the grants from Zhejiang Provincial Natural Science Foundation of China(No.LT-GY23H180001),Medical Health Science and Technology Project of Zhejiang Provincial Health Commission(No.2022KY230,No.2024KY132)and Research Project of Zhejiang Chinese Medical University(No.2022FSYYZY08)(All to Linyu WU).
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