中国肺癌杂志2025，Vol.28Issue(4)：309-318,10.DOI:10.3779/j.issn.1009-3419.2025.106.11
抗肺癌药物相关间质性肺病的研究进展
Research Progress of Anti-lung Cancer Drug-related Interstitial Lung Disease
摘要
Abstract
Lung cancer is the cancer with the highest incidence and mortality rate worldwide.In addition to the diversified treatment and prolonged lifespan in view of the development of medical technology,the side effect of medicine should not be ignored.Drug-induced interstitial lung disease(DI-ILD)is also commonly encountered during this process,and ILD triggered by the treatment of lung cancer characterized by the inflammation and scarring of lung tissue after the antitumor treatment in lung cancer leads to a poor prognosis and high mortality.The diagnosis and treatment of ILD caused by anti-lung cancer agents remains challenging in clinical settings and requires joint efforts from multidisciplinary team(MDT).This review systematically updates the epidemiology,molecular pathogenesis,genomics/genetics study,diagnosis and treatment of ILD related to anti-lung cancer agents.By the integration of the latest evidences,the paper offers clinical work references for early diagnosis of ILD related to anti-lung cancer agents to enhance the survival and quality of life of the lung cancer patients.关键词
肺肿瘤/抗肺癌药物/药物性间质性肺病/酪氨酸激酶抑制剂/免疫检查点抑制剂/多学科协作Key words
Lung neoplasms/Anti-lung cancer drugs/Drug-induced interstitial lung disease/Tyrosine kinase in-hibitors/Immune checkpoint inhibitors/Multidisciplinary collaboration引用本文复制引用
肖志敏,顾岩..抗肺癌药物相关间质性肺病的研究进展[J].中国肺癌杂志,2025,28(4):309-318,10.基金项目
本文受内蒙古医科大学科技创新团队胸膜疾病诊疗创新团队(No.YKD2022TD013)、内蒙古自然科学基金联合项目(No.2023LHMS08062)、国自然培育项目(No.2023NYFYPY005)和内蒙古医学科学院重点项目公立医院科研联合基金科技项目(No.2024GLLH0314)资助 This paper was supported by the grants from Inner Mongolia Medical University Science and Technology Inno-vation Team-Pleural Disease Diagnosis and Treatment Innovation Team(No.YKD2022TD013),Inner Mongolia Natu-ral Science Foundation Joint Project(No.2023LHMS08062),National Natural Science Foundation Cultivation Project(No.2023NYFYPY005),Inner Mongolia Medical Academy Key Project-Public Hospital Research Joint Fund Science and Technology Project(No.2024GLLH0314)(All to Yan GU). （No.YKD2022TD013）
