中国肺癌杂志2025，Vol.28Issue(4)：319-324,6.DOI:10.3779/j.issn.1009-3419.2025.102.15
ZDHHC介导的蛋白质棕榈酰化在NSCLC发生发展及免疫逃逸中的研究进展及其应用
Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation in the Development and Immune Escape of Non-small Cell Lung Cancer
摘要
Abstract
Non-small cell lung cancer(NSCLC),a leading cause of cancer-related deaths worldwide,remains a sig-nificant clinical challenge despite advances in immune checkpoint inhibitors therapy,with drug resistance persisting as a major obstacle.Palmitoylation,a critical post-translational modification(PTM)primarily catalyzed by palmitoyltransferases of the zinc finger DHHC-type(ZDHHC),has recently demonstrated important implications in NSCLC.This review aims to eluci-date the mechanisms and clinical potential of ZDHHC-mediated protein palmitoylation in NSCLC progression and immune escape.关键词
肺肿瘤/ZDHHC酶/蛋白质棕榈酰化/免疫逃逸/PD-L1Key words
Lung neoplasms/ZDHHC enzymes/Protein palmitoylation/Immune escape/PD-L1引用本文复制引用
陈王成,庞丽丽,兰月梅,史彦红,文兵兵,张百红..ZDHHC介导的蛋白质棕榈酰化在NSCLC发生发展及免疫逃逸中的研究进展及其应用[J].中国肺癌杂志,2025,28(4):319-324,6.基金项目
本文受甘肃省自然科学基金项目(No.22JR5RA007)和联勤保障部队第九四○医院课题(No.2021yx052)资助 This paper was supported by the grants from Natural Science Foundation of Gansu Province(No.22JR5RA007)and In-house Project the 940th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army(No.2021yx052)(Both to Baihong ZHANG). （No.22JR5RA007）
