中风与神经疾病杂志2025，Vol.42Issue(5)：427-433,7.DOI:10.19845/j.cnki.zfysjjbzz.2025.0081
线粒体病的治疗进展
Advances in the treatment of mitochondrial diseases
摘要
Abstract
Mitochondrial diseases are a group of hereditary disorders characterized by impaired oxidative phosphory-lation in the mitochondrial respiratory chain caused by defects in either mitochondrial DNA or nuclear DNA,and such dis-eases have complex and diverse clinical manifestations and often involve multiple organs and systems,with the main mani-festation of lesions in the nervous system and muscles due to their high energy demands.At present,there is still a lack of effective therapies for most mitochondrial diseases,and therefore,multidisciplinary management is essential in clinical practice,integrating various therapeutic approaches to provide personalized treatment regimens for patients with mitochon-drial diseases.The primary treatment principle involves the timely correction of pathological and physiological abnormali-ties through pharmacological interventions,dietary modifications,and exercise management,along with the prompt treat-ment of system-specific impairments and the prevention of potential complications.关键词
线粒体病/治疗/临床表现/诊断Key words
Mitochondrial diseases/Treatment/Clinical manifestations/Diagnosis分类
临床医学引用本文复制引用
王佳音,庄星宇,王佳宁,纪坤乾,焉传祝..线粒体病的治疗进展[J].中风与神经疾病杂志,2025,42(5):427-433,7.基金项目
国家自然科学基金(82171394,82371410) （82171394,82371410）
