中国感染控制杂志2025，Vol.24Issue(5)：705-711,7.DOI:10.12138/j.issn.1671-9638.20257091
真菌感染/定植生物膜形成机制与防治措施研究新进展
Research advances in biofilm formation mechanisms as well as prevention and control measures of fungal infection/colonization
摘要
Abstract
Fungal infection is an increasingly serious clinical problem,especially in immunocompromised patients.Fungi,such as Candida albicans,Aspergillus,and Cryptococcus,can form biofilm,which enhance their drug re-sistance and immune evasion ability,thus become major obstacles to the treatment of infection.Biofilm formation is not limited to human body,it can also form on the surface of medical devices,leading to chronic and recurrent infec-tion.This article elaborates the biofilm formation mechanisms and hazards caused by different fungi such as Candi-da albicans and Aspergillus,emphasizes immune suppression,chronic diseases,and medical devices as high-risk factors for biofilm formation.Fungi can form biofilm through multiple stages such as adhesion,proliferation,extra-cellular matrix(ECM)construction,and cell dispersion,and enhance drug resistance based on physical barriers and gene regulation.Although existing antifungal agents are effective in infection caused by planktonic fungi,their treatment efficacy on fungal biofilm is limited.Therefore,the article explores new treatment strategies,including non-pharmacological therapies such as photodynamic therapy and electric field therapy,as well as targeted gene edi-ting and the application of new biomaterials.It is necessary to strengthen the combination of basic research and clini-cal applications,develop efficient and low toxicity treatment scheme to improve the successful treatment rate for patients.关键词
生物膜/真菌感染/抗真菌药物/真菌耐药性/免疫抑制宿主Key words
biofilm/fungal infection/antifungal agent/drug resistance of fungus/immunocompromised host分类
基础医学引用本文复制引用
钱贤晢,张庶文,李春辉,向天新..真菌感染/定植生物膜形成机制与防治措施研究新进展[J].中国感染控制杂志,2025,24(5):705-711,7.基金项目
湖南省人才托举工程项目—中青年优秀科技人才培养计划(2023TJ-Z11) （2023TJ-Z11）
