中风与神经疾病杂志2025，Vol.42Issue(5)：440-446,7.DOI:10.19845/j.cnki.zfysjjbzz.2025.0083
颈动脉支架植入术对颈动脉狭窄患者脑白质高信号体积进展的影响
Impact of carotid artery stenting on the progression of white matter hyperintensity volume in patients with carotid artery stenosis
摘要
Abstract
Objective To investigate whether carotid artery stenting(CAS)is a protective factor against the pro-gression of white matter hyperintensity(WMH)volume in patients with carotid artery stenosis.Methods A prospective study was conducted for the clinical,imaging,and follow-up data of patients with carotid artery stenosis who were treated in Zhejiang Provincial People's Hospital from January 2021 to June 2023.A total of 99 participants were included in this study,among whom 48 received CAS treatment(CAS group)and 51 did not receive CAS treatment(non-CAS group).The two groups were analyzed in terms of baseline data and WMH volume during the 1-year follow-up.Results There were no significant differences in baseline data between the two groups(P>0.05).There was no significant difference in overall WMH volume after follow-up between the two groups(P>0.05),but compared with the non-CAS group,the CAS group showed a significantly lower degree of the progression of WMH volume within one year(-0.27 ml vs 2.82 ml,P<0.001).There was a significant difference in the proportion of patients with new-onset stroke within one year between the CAS group and the non-CAS group(18.75%vs 37.25%,P=0.041).The binary logistic regression analysis showed that CAS was an independent protective factor against the progression of WMH volume(OR=-0.37,95%CI-0.78 to-0.03,P=0.046)and new-onset stroke within one year(OR=0.28,95%CI 0.09 to 0.83,P=0.022).Conclusion CAS is a protective factor against the progression of WMH volume and can effectively reduce the risk of stroke recurrence in patients with ca-rotid artery stenosis.关键词
颈动脉狭窄/颈动脉支架植入术/脑白质高信号Key words
Carotid artery stenosis/Carotid artery stenting/White matter hyperintensity分类
临床医学引用本文复制引用
叶佳伟,韩露洁,沈盼盼,王培文,俞伟涛,王慧远,舒震宇,张圣,耿昱..颈动脉支架植入术对颈动脉狭窄患者脑白质高信号体积进展的影响[J].中风与神经疾病杂志,2025,42(5):440-446,7.基金项目
浙江省医药卫生科技计划项目(2024KY019) （2024KY019）
