中国感染控制杂志2025，Vol.24Issue(5)：712-720,9.DOI:10.12138/j.issn.1671-9638.20256620
髓源性抑制细胞(MDSCs)在结核病中的作用研究进展
Research progress on the role of myeloid-derived suppressor cells in tuber-culosis
摘要
Abstract
Tuberculosis,as a chronic infectious disease caused by Mycobacterium tuberculosis(MTB)infection,presenting a serious threat to human and animal health.When human body is infected by MTB,it quickly initiates an immune response,in which T lymphocyte-mediated cellular immunity plays a key role,as it can effectively recog-nize and eliminate MTB,serving as an important defense line for the body against MTB.However,during MTB in-fection process,myeloid-derived suppressor cells(MDSCs)undergo amplification and activation,which exhibit in-hibitory effect on the immune function of T lymphocytes and interfere the normal immune response of the body,making MTB easier to survive and reproduce in the body.This article discusses the role of MDSCs in the occu-rrence,development and prognosis of tuberculosis from two different perspectives,expects to provide new perspec-tives and ideas for the immunotherapy of tuberculosis as well as the research and development of targeted drugs,so as to open up a new way for the prevention and treatment of tuberculosis.关键词
结核分枝杆菌/髓源性抑制细胞/免疫抑制Key words
Mycobacterium tuberculosis/myeloid-derived suppressor cell/immunosuppression分类
临床医学引用本文复制引用
张佳雪,王晓平,刘莉,马沁梅,邓光存,吴晓玲..髓源性抑制细胞(MDSCs)在结核病中的作用研究进展[J].中国感染控制杂志,2025,24(5):712-720,9.基金项目
宁夏自然科学基金项目(2023AAC02015、2022AAC02009) （2023AAC02015、2022AAC02009）
国家自然科学基金项目(32060160、32160162) （32060160、32160162）
