中风与神经疾病杂志2025，Vol.42Issue(5)：447-453,7.DOI:10.19845/j.cnki.zfysjjbzz.2025.0084
初诊帕金森病感觉运动、联想和边缘环路的功能核磁研究
Sensorimotor,associative and limbic loops in patients with an initial diagnosis of Parkinson disease:A functional magnetic resonance imaging study
摘要
Abstract
Objective To investigate the changes in functional connectivity(FC)of cortical-striatal sensorimotor loop(mediating habit control),associative loop(regulating goal-directed behavior),and limbic loop in patients with an initial diagnosis of Parkinson disease(PD).Methods Resting-state functional magnetic resonance imaging data were collected from 41 PD patients and 31 healthy controls.The cortical and basal ganglia regions associated with the senso-rimotor,associative,and limbic loops were selected as regions of interest(ROIs),and FC between each region of interest was calculated.The magnetic resonance images of the more affected hemisphere were aligned to exclude severe lateraliza-tion of symptoms.The correlation analysis was conducted to investigate the correlation between FC and disease severity.Results The patients with PD showed a reduction in FC within the sensorimotor loop,specifically between the left dorso-lateral striatum and the left sensorimotor cortex(P<0.001),between the right dorsolateral striatum and the left sensorimo-tor cortex(P=0.004),and between the right dorsolateral striatum and the right sensorimotor cortex(P=0.004),and there was no significant change in FC within the associative loop.The patients with PD showed a reduction in FC within the lim-bic loop between the bilateral ventral striata(P<0.001).In the PD group,FC between the left dorsolateral striatum and the left sensorimotor cortex was negatively correlated with MDS-UPDRS Ⅲ score(r=-0.496,P=0.001),with consistent results after alignment of the side with more severe symptoms.Conclusion There is a pathological reduction in FC within the sensorimotor loop that is involved in habitual control in the early stage of PD,while the associative loop for regulating goal-directed behavior remains unaffected or may be involved in early compensatory processes.关键词
帕金森病/功能磁共振成像/皮质-纹状体环路/习惯性控制/目标导向行为Key words
Parkinson disease/Functional magnetic resonance imaging/Cortical-striatal loop/Habitual control/Goal-directed behavior分类
临床医学引用本文复制引用
赵辉,许敏,陈汝一,张伟,祖洁..初诊帕金森病感觉运动、联想和边缘环路的功能核磁研究[J].中风与神经疾病杂志,2025,42(5):447-453,7.基金项目
江苏省高校重点实验室开放项目(XZSYSKF2022039) （XZSYSKF2022039）
