摘要
Abstract
Objective To explore the effect of lung-protective ventilation on cerebral oxygen saturation and cognitive function in elderly patients undergoing laparoscopic colorectal cancer surgery.Methods Total 84 elderly patients undergoing laparoscopic colorectal cancer surgery were randomly divided into an observation group and a control group,with 42 cases in each group.The control group received convention-al ventilation,while the observation group adopted a lung-protective ventilation strategy.Cerebral oxygen saturation(rSO2),arterial partial pressure of carbon dioxide(PaCO2)levels at four time points[before anesthesia induction(T1),30 min after pneumoperitoneum(T2),60 min after pneumoperitoneum(T3),and 5 min after pneumoperitoneum closure(T4)],and postoperative cognitive function were compared be-tween the two groups.Results At T1,there were no significant differences in rSO2 or PaCO2 levels be-tween the two groups(P＞0.05).At T2,T3,and T4,rSO2 levels in the observation group were signifi-cantly higher than those in the control group(P＜0.05),while PaCO2 levels were lower than those in the control group(P＜0.05).There was no significant difference in the scores of Mini-Mental State Examina-tion(MMSE)between the two groups before surgery(P＞0.05),and the MMSE scores of the observa-tion group were higher than those of the control group 1 day after surgery(P＜0.05).Conclusion Lung-protective ventilation improves cerebral oxygen saturation during and after pneumoperitoneum,re-duces PaCO2 levels,and demonstrates advantages in maintaining cerebral oxygenation.Lung-protective ventilation can help reduce the risk of brain injury in elderly patients undergoing laparoscopic surgery and better improve their postoperative cognitive function.关键词
结直肠癌/腹腔镜/手术/老年/肺保护性通气/脑氧饱和度/认知功能Key words
Colorectal cancer/Laparoscope/Surgery/Elderly/Lung-protective ventilation/Cerebral oxy-gen saturation/Cognitive function
