中国感染控制杂志2025，Vol.24Issue(5)：591-596,6.DOI:10.12138/j.issn.1671-9638.20256486
HIV阴性患者马尔尼菲篮状菌和非结核分枝杆菌共感染的临床特征
Clinical characteristics of co-infection of Talaromyces marneffei and non-tuberculous Mycobacterium in HIV-negative patients
摘要
Abstract
Objective To analyze the clinical characteristics of co-infection of Talaromyces marneffei(TM)and non-tuberculous Mycobacterium(NTM)in human immunodeficiency virus(HIV)-negative patients.Methods Clinical data of 8 HIV-negative patients with co-infection of TM and NTM in a hospital from 2019 to 2022 were co-llected.Clinical manifestations,auxiliary examination,treatment and prognosis were retrospectively analyzed.Results Among the 8 patients,5 were females and 3 were males,with an average age of(52.25±12.31)years old.All patients presented TM and NTM disseminated infection.The major involved organs were lung(100％),lymph nodes(87.5％),and skin(75.0％).Clinical symptoms mainly included cough and expectoration(87.5％),fatigue(62.5％),joint and lumbosacral pains(62.5％),fever(50.0％),as well as skin and soft tissue abscess(50.0％),etc.Anti-interferon-γ(INF-γ)autoantibodies were detected in 4 patients and the results were positive.All 8 patients(100％)had pulmonary lesions,with chest CT mainly showing spots,patches,and striped shadows in both lungs.Among them,7 cases(87.5％)had increased and enlarged mediastinal lymph nodes,4 cases(50.0％)had pleural thickening and pleural effusion,2 cases each(25.0％for each)were accompanied by pulmonary mass shadows,bronchial stenosis,as well as increased and enlarged hilar lymph nodes.One case each(12.5％for each)had pulmonary cavity formation,bronchiectasis,and pericardial effusion.Conclusion The co-infection of TM and NTM in non-HIV patients presents disseminated infection,with multiple clinical symptoms.Chest imaging shows a wide variety of pulmonary lesions.It is prone to miss diagnosis in clinic,and the effect is not ideal after treatment for single pathogen infection.关键词
马尔尼菲篮状菌/非结核分枝杆菌/成人自身免疫缺陷综合征/抗γ-干扰素自身抗体/HIV阴性患者Key words
Talaromycesmarneffei/non-tuberculous Mycobacterium/human immunodeficiency syndrome/anti-interferon-γ autoantibody/HIV-negative patient分类
临床医学引用本文复制引用
李莎,谢小雁,梁婷婷,刘骏,何耀钦,冯凤泉,黄美祯,李倩..HIV阴性患者马尔尼菲篮状菌和非结核分枝杆菌共感染的临床特征[J].中国感染控制杂志,2025,24(5):591-596,6.基金项目
南宁市科学研究与技术开发计划课题(20213025-4) （20213025-4）
