中国感染控制杂志2025，Vol.24Issue(5)：597-601,5.DOI:10.12138/j.issn.1671-9638.20257261
79例西弗射盾子囊霉感染患者临床特点及其耐药性
Clinical characteristics and antifungal resistance of 79 patients infected with Stephanoascus ciferrii complex
摘要
Abstract
Objective To explore the clinical infection distribution and antifungal resistance characteristics of the Stephanoascusciferrii(S.ciferrii)complex.Methods Clinical fungal culture and isolation data from Nanjing Drum Tower Hospital from 2012 to 2023 were retrospectively analyzed.The annual isolation quantity,proportion,and distribution of infection sites of S.ciferrii were statistically analyzed.The minimum inhibitory concentrations(MICs)of isolated strains against common antifungal agents were detected by ATB Fungus 3 fungal susceptibility test kit,and their resistance was analyzed.Results From 2012 to 2023,a total of 26 602 fungal strains were isola-ted in this hospital,including 79 strains of the S.ciferrii complex.Compared with 2012-2017,the isolation rate of S.ciferrii complex increased from 2018 to 2023(0.06％vs 0.43％,P＜0.001).There were 69 cases of super-ficial infection,including infection of ear canal(n=67)and skin(n=2).92.75％(n=64)of the patients were im-munocompetent individuals.There were 10 cases of invasive infection,including infection of urinary tract(n=5),respiratory tract(n=2),biliary tract(n=1),pacemaker pouch(n=1),and vagina(n=1).70.00％of the pa-tients had other underlying diseases,including 3 cases of immunosuppressed patients who died due to combined in-fection with the S.ciferrii complex.The MICs detection results showed that the MIC50 and MIC90 of fluconazole were 32 μg/mL and 128 μg/mL,respectively;the MIC50 and MIC90 of amphotericin B were 0.5 μg/mL and 2 μg/mL,respectively.Conclusion S.ciferrii complex mainly causes ear canal infection and has the dual pathogenic ability to cause superficial and invasive infection.The isolated strains showed higher MIC values for fluconazole and lower MIC values for amphotericin B.The mortality is high in immunosuppressed patients combined with invasive infec-tion caused by S.ciferrii.关键词
西弗射盾子囊霉复合群/临床特点/真菌/耐药性Key words
Stephanoascus ciferrii complex/clinical characteristics/fungus/drug resistance分类
临床医学引用本文复制引用
范柏源,徐士兰,高硕,王涵东,周万青..79例西弗射盾子囊霉感染患者临床特点及其耐药性[J].中国感染控制杂志,2025,24(5):597-601,5.基金项目
南京市医学科技发展资金项目(QRX17143) （QRX17143）
