代谢综合征合并脑小血管病相关睡眠障碍的研究进展OA

The incidence of metabolic syndrome(MS),cerebrovascular disease(CSVD)and sleep disorder,often occur together,Previous studies were mostly limited to the direction of a single disease.With the deepening of the study,it was found that the inci-dence rate of sleep disorders in MS patients with CSVD was significantly increased,and the risks of MS and CSVD in patients with sleep disorders were also significantly increased.The three are closely related and the pathogenesis is partially overlapping.This arti-cle summarizes the common mechanisms of MS,CSVD,and sleep disorders,and analyzes the causes of sleep disorders.The common mechanism between MS and CSVD involves insulin resistance,fatty acid metabolism disorders,oxidative stress,and chronic inflam-mation.The common mechanisms of MS and sleep disorders involve insulin resistance,obesity,oxidative stress,and metabolic disor-ders.The circulatory mechanism of CSVD and sleep disorders involves neurological dysfunction,chronic cerebral ischemia,and hy-poperfusion.The impact of MS on sleep disorders can be divided into respiratory and non respiratory problems,with respiratory prob-lems mainly being obstructive sleep apnea hypopnea syndrome.The impact of CSVD on sleep disorders is mainly related to brain tis-sue damage caused by cerebral hypoperfusion and fluid regulation factors.Through comprehensive analysis,the above three factors are each other's risk factors,which can accelerate their respective development processes and ultimately form a vicious cycle.Early as-sessment and timely intervention can help break this vicious cycle.