中国医院用药评价与分析2025，Vol.25Issue(5)：545-548,554,5.DOI:10.14009/j.issn.1672-2124.2025.05.007
N-乙酰半胱氨酸对多发性硬化患者氧化应激、精神状态的影响
Effects of N-Acetylcysteine on Oxidative Stress and Mental State in Patients with Multiple Sclerosis
摘要
Abstract
OBJECTIVE:To probe into the effects of N-acetylcysteine(NAC)on oxidative stress and mental state in patients with multiple sclerosis(MS).METHODS:A total of 112 MS patients admitted into the hospital from Aug.2022 to Jul.2024 were enrolled to be divided into the NAC group and control group via random number table method,with 56 cases in each group.The NAC group was given acetylcysteine effervescent tablets,600 mg once,for twice a day,the control group was given placebo,both groups were treated continuously for 6 weeks.The oxidative stress indicators,mental state indicators,inflammatory indicators and incidences of adverse drug reactions were compared between NAC group and control group.RESULTS:After treatment,the serum nitric oxide[(36.60±10.25)μmol/L vs.(40.93±10.71)μmol/L,t=2.186,P=0.029]and malondialdehyde[(11.19±4.33)μmol/L vs.(13.63±4.98)μmol/L,t=2.166,P=0.033]levels were significantly lower in the NAC group than those in the control group,while the superoxide dismutase[(106.80±12.13)U vs.(81.07±9.66)U,t=12.306,P<0.001]and glutathione[(0.49±0.15)mmol/L vs.(0.40±0.17)mmol/L,t=2.944,P=0.004]levels were significantly higher in the NAC group than those in the control group,with statistically significant differences.After treatment,the scores of Hospital Anxiety and Depression Scale-Anxiety Subscale and Hospital Anxiety[(8.05±1.57)points vs.(9.39±1.38)points,t=4.754,P<0.001]and Depression Scale-Depression Subscale[(6.39±1.47)points vs.(8.46±1.52)points,t=7.326,P<0.001]were significantly lower in the NAC group than those in the control group,while the score of Mini-Mental State Examination[(28.05±1.62)points vs.(25.16±2.09)points,t=8.745,P<0.001]was significantly higher in the NAC group than that in the control group,with statistically significant differences.After treatment,the differences in blood indicators between the NAC group and control group were not statistically significant(P>0.05).After treatment,the interleukin-16(t=10.322,P<0.001),interleukin-23(t=9.542,P<0.001)and tumor necrosis factor α(t=7.903,P<0.001)levels were significantly lower in the NAC group than those in the control group,with statistically significant differences.The differences in the incidences of adverse drug reactions between the NAC group and control group were not statistically significant[1.8%(1/56)vs.0%(0/56),χ2=1.009,P=0.315].CONCLUSIONS:After oral administration of NAC in MS patients,MS patients shows a significant decrease in oxidative stress,a significant improvement in anxiety and depression symptoms and cognitive function,and no significant increase in the incidence of adverse drug reactions.关键词
N-乙酰半胱氨酸/氧化应激/精神状态Key words
N-acetylcysteine/Oxidative stress/Mental state分类
药学引用本文复制引用
封亮,高春霞,王文娥,王喜丹,周菁菁,陈鸣..N-乙酰半胱氨酸对多发性硬化患者氧化应激、精神状态的影响[J].中国医院用药评价与分析,2025,25(5):545-548,554,5.基金项目
2022年陕西省卫健委卫生健康科研基金项目(No.2022yb389) （No.2022yb389）
