中国医院用药评价与分析2025，Vol.25Issue(5)：549-554,6.DOI:10.14009/j.issn.1672-2124.2025.05.008
基于潜在类别分析的冠心病患者共病模式下的用药偏好研究
Study of Medication Preference in Patients with Coronary Heart Disease in Comorbid Mode Based on Latent Class Analysis
摘要
Abstract
OBJECTIVE:To analyze the medication preferences of patients with coronary heart disease under different comorbidities based on latent class analysis,and to summarize the clinical drug combinations under different comorbidities.METHODS:The effective medical records of 2 330 patients with coronary heart disease from different levels of medical institutions in a city in Shanxi Province from Jan.2022 to Jan.2023 were collected,and potential category analysis was used to group coronary heart disease comorbidities,the complex network of drugs used in each subgroup was constructed.RESULTS:The comorbid population of coronary heart disease could be divided into three potential subgroups,namely the the elderly organic lesion group,metabolic disease group,and low comorbidity burden group.Among them,core drugs in the elderly organic lesion group were anticoagulants,Chinese patent medicines,diuretics and blood-lipid modulators.Core drugs in the metabolic disease group were blood-lipid modulators,anticoagulants,antiplatelet drugs,Chinese patent medicines and β-blockers.Core drugs in the low comorbidity burden group were blood-lipid modulators,anticoagulants,and antiplatelet agents.CONCLUSIONS:There is population heterogeneity in the comorbidity of patients with coronary heart disease,which can be divided into three subgroups.There are differences in the medication preference of coronary heart disease in different subgroups.It is suggested to focus on the drugs recommended by the guidelines and improve the therapeutic effect of drugs and promote the rational use of drugs through measures such as formulating relevant policies,establishing the essential drug system and standardizing medical services.关键词
冠心病/共病/用药偏好/潜在类别分析/网络分析Key words
Coronary heart disease/Comorbidities/Medication preferences/Latent class analysis/Network analysis分类
药学引用本文复制引用
杨雅棋,朱裕,崔岩,闫娟娟..基于潜在类别分析的冠心病患者共病模式下的用药偏好研究[J].中国医院用药评价与分析,2025,25(5):549-554,6.基金项目
山西省中医药管理局中医药创新团队建设计划(No.zyytd2024025) （No.zyytd2024025）
山西省中医药管理局科研计划项目(No.2024ZYYAD007) （No.2024ZYYAD007）
