中国医院用药评价与分析2025，Vol.25Issue(5)：568-572,5.DOI:10.14009/j.issn.1672-2124.2025.05.012
参一胶囊联合双歧杆菌三联活菌片对类风湿关节炎患者肠道菌群数量和免疫功能的影响
Effects of Shenyi Capsules Combined with Live Combined Bifidobacterium and Lactobacillus Tablets on Intestinal Flora Number and Immune Function in Patients with Rheumatoid Arthritis
摘要
Abstract
OBJECTIVE:To probe into the effects of Shenyi capsules combined with Live combined bifidobacterium and lactobacillus tablets on intestinal flora number and immune function in patients with rheumatoid arthritis(RA).METHODS:A total of 96 RA patients admitted into this hospital from Sept.2020 to Sept.2023 were selected to be divided into conventional group(48 cases)and combined group(48 cases)via random number table method.The conventional group was given methotrexate and leflunomide,while the combined group was given Shenyi capsules combined with Live combined bifidobacterium and lactobacillus tablets based on the conventional group,both groups were treated continuously for 2 months.The clinical efficacy,intestinal flora number,assessment of disease activity,bone metabolism indicators,serum inflammatory factors,immune indicators and incidences of adverse drug reactions of both groups after treatment were observed.RESULTS:After treatment,the total effective rate of combined group was 93.75%(45/48),which was significantly higher than 72.92%(35/48)of the conventional group,with statistically significant difference(P<0.05).After treatment,the numbers of lactobacillus and bifidobacterium,total procollagen I N-terminal propeptide,N-terminal middle molecular of osteocalcin,T lymphocytes CD3+,CD4+and CD4+/CD8+of both groups were significantly higher than those before treatment,and those of the combined group were significantly higher than the conventional group,with statistically significant difference(P<0.05).The number of Escherichia coli,β-collagen degradation products,disease activity scores of 28 joints,simplified disease activity index and clinical disease activity index,interleukin-6,erythrocyte sedimentation rate,tumor necrosis factor α,C-reactive protein,immunoglobulin(Ig)A,IgG and IgM levels of both groups were significantly lower than those before treatment,and those of the combined group were significantly lower than the conventional group,with statistically significant difference(P<0.05).The total incidence of adverse drug reactions of the combined group was 8.33%(4/48),the difference was not statistically significant(P>0.05)when compared with 18.75%(9/48)in the conventional group.CONCLUSIONS:The combination of Shenyi capsules and Live combined bifidobacterium and lactobacillus tablets in the treatment of RA can promote clinical efficacy,regulate intestinal flora,reduce inflammatory reactions,improve bone metabolism indicators and some cellular immune function,and reduce disease activity.关键词
甲氨蝶呤/参一胶囊/类风湿关节炎/双歧杆菌三联活菌片/肠道菌群数量Key words
Methotrexate/Shenyi capsules/Rheumatoid arthritis/Live combined bifidobacterium and lactobacillus tablets/Intestinal flora number分类
医药卫生引用本文复制引用
陶然,崔欣,付妍妍,闫晓雯,孙晓..参一胶囊联合双歧杆菌三联活菌片对类风湿关节炎患者肠道菌群数量和免疫功能的影响[J].中国医院用药评价与分析,2025,25(5):568-572,5.基金项目
河北省卫生健康委员会2024年度医学科学研究课题计划(No.20240691) （No.20240691）
