中国医院用药评价与分析2025，Vol.25Issue(5)：584-589,6.DOI:10.14009/j.issn.1672-2124.2025.05.015
口服中药治疗感染后咳嗽的疗效及安全性的系统评价及Meta分析
Systematic Review and Meta-Analysis on Efficacy and Safety of Oral Administration of Traditional Chinese Medicine in the Treatment of Post-Infection Cough
摘要
Abstract
OBJECTIVE:To systematically review the clinical efficacy and safety of oral administration of traditional Chinese medicine in the treatment of post-infection cough.METHODS:Randomized controlled trials on oral administration of traditional Chinese medicine in the treatment of post-infection cough(the observation group was given oral administration of traditional Chinese medicine,including traditional Chinese medicine decoction and traditional Chinese medicine granules;the control group received blank control,placebo or Western medicine)published from database establishment to Jun.30th,2024 were collected by searching 7 Chinese and English databases.Literature screening and quality assessment were conducted according to the Cochrane criterion,Meta-analysis on the enrolled studies was performed and GRADE framework was used to evaluate the evidence.RESULTS:A total of 16 studies were enrolled,including 2 894 patients.Meta-analysis showed that oral administration of traditional Chinese medicine had better efficacy in improving clinical total clinical effective rate(RR=1.19,95%CI=1.15-1.23),reducing daytime cough symptom score(SMD=-0.98,95%CI=-1.46--0.51),nighttime cough symptom score(SMD=-1.21,95%CI=-1.76--0.67)and traditional Chinese medicine syndrome score(SMD=-1.11,95%CI=-1.65--0.57),and reducing neuropeptide substance P(SMD=-2.86,95%CI=-4.39--1.33),interleukin-6(SMD=-1.93,95%CI=-3.29--0.57),neurokinin A(SMD=-1.11,95%CI=-1.45--0.77)levels than those in the control group,and oral administration of traditional Chinese medicine had lower case number of adverse drug reaction than that of the control group(OR=0.53,95%CI=0.35-0.80),with statistically significant differences(P<0.05).However,there was no statistically significant difference in the comparison of quality of life scores between the observation group and control group(SMD=0.40,95%CI=-0.31-1.10,P=0.27).GRADE classification showed that the total effective rate and case number of adverse drug reaction were high-quality evidence.CONCLUSIONS:Oral administration of traditional Chinese medicine in the treatment of post-infection cough has definite efficacy and safety,yet there are problems such as low quality and high heterogeneity of enrolled studies,which still needs high-quality RCT evidence.关键词
感染后咳嗽/中医药/Meta分析/GRADE评价Key words
Post-infection cough/Traditional Chinese medicine/Meta-analysis/GRADE assessment分类
医药卫生引用本文复制引用
杨琳,鲁震,卢丹妮,杨海燕,李宁,张群,冯原..口服中药治疗感染后咳嗽的疗效及安全性的系统评价及Meta分析[J].中国医院用药评价与分析,2025,25(5):584-589,6.基金项目
国家自然科学基金地区科学基金项目(No.81960804) （No.81960804）
广西自然科学基金面上项目(No.2023GXNSFAA02609) （No.2023GXNSFAA02609）
广西青年岐黄学者培养项目(No.GXQH202417) （No.GXQH202417）
