中华耳科学杂志2025，Vol.23Issue(3)：448-453,6.DOI:10.3969/j.issn.1672-2922.2025.03.017
不同麻醉维持方案对小型猪听觉电生理指标的影响
Effects of Anesthesia Maintenance Protocols on Electrophysiological Auditory Indicators in Miniature Pigs
摘要
Abstract
Objective This study evaluates electrophysiological auditory indicators under different anesthesia maintenance protocols in miniature pigs,for selection of optimal anesthesia protocols in otology research with miniature pigs.Methods After induction using Zoletil+Xylazine,1.5%isoflurane,2%isoflurane or intravenous Zoletil+Xylazine were used for anesthesia maintenance.Electrophysiological auditory indicators were evaluated at the initial stage of anesthesia,and at 60 minutes and 180 minutes post-induction.Results Along with extension of anesthesia time,CAP N1 latency prolonged with 1.5%isoflurane inhalation;CAP N1 amplitudes increased with prolonged N1 latency at 2 kHz andⅠ-Ⅴintervals of ABRs to tone pips at 2 and 16 kHz prolonged with 2%isoflurane inhalation;with the Zoletil+Xylazine protocol,CAP N1 latency was prolonged with increased amplitudes at 8 kHz,as well as increased CM amplitude at 2 kHz,and ABR thresholds to tone pips at 16 kHz were elevated with prolonged ABRⅠ-Ⅴintervals.Conclusion Of the three anesthesia maintenance regimens,1.5%isoflurane inhalation does not affect ABR and CAP thresholds,with relatively minor impacts on other indicators,making it the optimal anesthesia maintenance regimen.关键词
麻醉维持/小型猪/听性脑干反应/耳蜗电图Key words
anesthesia maintenance/miniature pigs/auditory brainstem response/electrocochleography引用本文复制引用
柳红东,杨仕明,陈志峰,胡云,李娟娟,杨虓,高云,曾宪海,戢小军,陈伟..不同麻醉维持方案对小型猪听觉电生理指标的影响[J].中华耳科学杂志,2025,23(3):448-453,6.基金项目
国家重点研发计划项目(2022YFC2402701) （2022YFC2402701）
"春城计划"高层次引进培养工程(2022SCP001) （2022SCP001）
解放军总医院第六医学中心创新培育基金(CXPY202302) （CXPY202302）
