中国医学装备2025，Vol.22Issue(5)：33-37,5.DOI:10.3969/j.issn.1672-8270.2025.05.007
基于CA125水平升高18F-FDG PET/CT对卵巢癌患者术后复发或转移诊断价值的Meta分析
Meta-analysis of the diagnostic value of 18F-FDG PET/CT in postoperative recurrence or metastasis of ovarian cancer patients with elevated CA125 levels
摘要
Abstract
Objective:To systematically review the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT)on recurrence or metastasis of patients with ovarian cancer whose postoperative serum carbohydrate antigen 125(CA125)occurred abnormal elevation.Methods:A systematic search was conducted in foreign databases,including PubMed,Embase,Cochrane Library(Central)and Web of Science(SCI-Expanded),as well as Chinese databases,such as China National Knowledge Infrastructure(CNKI),VIP Network,Wanfang Database,and China Biology Medicine(CBM),for the studies that were published between January 2010 and January 2023 on the diagnostic value of 18F-FDG PET/CT on recurrence or metastasis of patients with ovarian cancer whose postoperative serum CA125 levels occurred abnormal elevation.The quality of the included studies was assessed by using the QUADAS-2 quality evaluation tool in Review Manager 5.4 software.The effective data were extracted,and effect quantities were merged,and heterogeneity test was conducted through Meta-Disc 1.4 software.Publication bias of the included studies was tested by using Stata 14.0 software.Results:A total of seven literatures were involved in this research,and 290 patients with ovarian cancer were included to conduct heterogeneity test,which revealed I2 values all were greater than 50%.Therefore,the a fixed-effect model was used to merge effect quantity.The results demonstrated that the diagnostic accuracy was higher,and the sensitivity,specificity,positive likelihood ratio,negative likelihood ratio,and diagnostic odds ratio(DOR)of the mergement were respectively 0.95(95%CI:0.91-0.98),0.83(95%CI:0.70-0.92),4.84(95%CI:2.82-8.31),0.07(95%CI:0.04-0.13)and 73.53(95%CI:28.00-187.90).The area under curve(AUC)value of receiver operating characteristic curve(AUC)was 0.9527,and the diagnostic accuracy of 18F-FDG PET/CT for metastasis or recurrence in patients with ovarian cancer,whose postoperative serum CA125 levels occurred elevation,reached to 95.27%.Publication bias testing showed there was no evidence of publication bias.Conclusion:18F-FDG PET/CT exhibits higher accuracy in diagnosing recurrence or metastasis in patients with ovarian cancer whose postoperative serum CA125 levels occurred elevation,which can sensitively and accurately confirmed postoperative recurrence or metastasis of patients with ovarian cancer,and early find the lesions of metastasis or recurrence of ovarian cancer.关键词
卵巢癌/肿瘤标志物糖类抗原(CA125)/氟18氟代脱氧葡萄糖(18F-FDG)/正电子发射计算机断层显像与计算机断层显像(PET/CT)/系统评价/Meta分析Key words
Ovarian cancer/Carbohydrate antigen 125(CA125)/18F-fluorodeoxyglucose(18F-FDG)/Positron emission tomography/computed tomography(PET/CT)/Systematic review/Meta-analysis分类
医药卫生引用本文复制引用
苗春燕,刘大湃,高富,俞承成,曼菲达·买买提,蒲武涛,夏露花..基于CA125水平升高18F-FDG PET/CT对卵巢癌患者术后复发或转移诊断价值的Meta分析[J].中国医学装备,2025,22(5):33-37,5.基金项目
新疆医科大学大学生创新训练项目(S202310760058) （S202310760058）
教育部产学合作协同育人项目(230805236315631) Xinjiang Medical University Undergraduate Innovation Training Program(S202310760058) （230805236315631）
Ministry of Education Industry-University Cooperation and Coordinated Talent Cultivation Program(230805236315631) （230805236315631）
