中国医院用药评价与分析2025，Vol.25Issue(5)：604-609,6.DOI:10.14009/j.issn.1672-2124.2025.05.019
外用藏药复方制剂治疗软组织损伤的有效性和安全性的Meta分析
Meta-Analysis on Efficacy and Safety of Topical Tibetan Medicine Compound Preparation in the Treatment of Soft Tissue Injury
摘要
Abstract
OBJECTIVE:To systematically evaluate the efficacy and safety of external Tibetan medicine compound preparation in the treatment of soft tissue injury,with the aim of providing evidence-based medical evidence for related clinical decisions.METHODS:CNKI,Wanfang Data,VIP,CBM,ChiCTR,the Cochrane Library,PubMed and Embase databases were retrieved to collect randomized controlled trials[the research group was treated with one of the three drugs:Xiaotong plaster,Qingpeng plaster(Qingpeng soft plaster),and Xueshan Jinluohan analgesia film;while the control group received either conventional traditional Chinese medicine or Western medicine]of external Tibetan medicine compound preparation in the treatment of soft tissue injury.The retrieval time was from the establishment of the database to Jun.2023.Two investigators independently screened the literature,extracted data,and assessed the risk of bias of the included studies.The Cochrane bias risk assessment tool RoB 2.0 was used to analyze the risk of bias,and the RevMan 5.3 software was used to conduct Meta-analysis on the total response rate,Visual Analogue Scale(VAS)score for pain,clinical symptom score,safety evaluation and other contents of the literature.RESULTS:A total of 26 studies with 2 925 patients were included.Meta-analysis showed that the total effective rate(RR=1.15,95%CI=1.11-1.18,P<0.000 01),VAS score for pain(MD=0.70,95%CI=0.27-1.14,P=0.002),pain symptom score(MD=0.45,95%CI=0.04-0.86,P=0.03),tenderness symptom score(MD=0.41,95%CI=0.32-0.50,P<0.000 01),swelling symptom score(MD=0.24,95%CI=0.14-0.34,P<0.000 01),dysfunction symptom score(MD=0.59,95%CI=0.17-1.01,P=0.006)in the research group were better than those in the control group,with statistically significant differences.There was no statistically significant difference in the red fever symptom scores and the incidence of adverse drug reactions between two groups(P>0.05).Funnel plot of the total effective rate suggested that there was publication bias.CONCLUSIONS:External Tibetan medicine compound preparation are superior to conventional treatment of traditional Chinese medicine or Western medicine in the treatment of soft tissue injury.Further improvement of such research is still needed in the future.关键词
藏药/软组织损伤/随机对照试验/Meta分析Key words
Tibetan medicine/Soft tissue injury/Randomized controlled trial/Meta-analysis分类
医药卫生引用本文复制引用
那娜,訾明杰,陈进成,李若琪..外用藏药复方制剂治疗软组织损伤的有效性和安全性的Meta分析[J].中国医院用药评价与分析,2025,25(5):604-609,6.基金项目
中国中医科学院科技创新工程创新团队课题(No.CI2021B003) （No.CI2021B003）
中国中医科学院创新工程课题(No.CI2021A00703) （No.CI2021A00703）
