中国医院用药评价与分析2025，Vol.25Issue(5)：614-618,5.DOI:10.14009/j.issn.1672-2124.2025.05.021
365例肺结核患者抗结核药物相关药品不良反应发生情况及影响因素分析
Occurrence and Influencing Factors of Adverse Drug Reactions Related to Anti-Tuberculosis Drugs in 365 Patients with Pulmonary Tuberculosis
摘要
Abstract
OBJECTIVE:To probe into the occurrence of adverse drug reactions(ADR)during the application of anti-tuberculosis drugs and analyze the influencing factors.METHODS:Medical records of 365 patients with pulmonary tuberculosis admitted into the Karamay Hospital of People's Hospital of Xinjiang Uygur Autonomous Region from Mar.2021 to Dec.2023 were retrospectively retrieved.The basic information,life style habits,drug usage and other data were collected.Occurrence of ADR,clinical manifestations and severity during the treatment process were recorded.Univariate and multivariate Logistic regression analysis were used to investigate the influencing factors of ADR related to anti-tuberculosis drugs.RESULTS:A total of 365 patients primarily received first-line anti-tuberculosis drugs during treatment,including rifampin,isoniazid and pyrazinamide.Totally 153 ADR occurred,with an incidence of 41.92%.The main ADR were gastrointestinal reactions(47 cases,30.72%),allergic reactions(37 cases,24.18%),liver damage(29 cases,18.95%),kidney damage(16 cases,10.46%),musculoskeletal damage(15 cases,9.80%),and nervous system damage(9 cases,5.88%).Univariate analysis revealed that age,history of hypertension and history of diabetes were risk factors for ADR related to anti-tuberculosis drugs(P<0.05).Multivariate analysis indicated that age was closely associated with ADR related to anti-tuberculosis drugs(P<0.05).CONCLUSIONS:During anti-tuberculosis drug treatment,various ADR are common,with gastrointestinal reactions,allergic reactions and liver damage being the most frequent.Elderly patients with history of hypertension and history of diabetes should be closely monitored for ADR,and early intervention measures should be taken to improve medication safety.关键词
肺结核/抗结核药物/药品不良反应/影响因素/用药安全性Key words
Tuberculosis/Anti-tuberculosis drugs/Adverse drug reaction/Influencing factors/Medication safety分类
医药卫生引用本文复制引用
施洋,赵俊芳,候宝林,朱玉婧,吴胜利..365例肺结核患者抗结核药物相关药品不良反应发生情况及影响因素分析[J].中国医院用药评价与分析,2025,25(5):614-618,5.基金项目
国家卫健委医药卫生科技重大专项(No.2023ZD0508106) （No.2023ZD0508106）
新疆维吾尔自治区药品临床综合评价项目(No.XJWJYZ202421) （No.XJWJYZ202421）
新疆维吾尔自治区药学会科研基金资助项目(No.YXH202412) （No.YXH202412）
克拉玛依市首届科技创新人才培养项目(No.克科发[2023]1号) （No.克科发[2023]1号）
克拉玛依市创新环境建设计划(软科学)项目(No.2024hjrkx0040) （软科学）
