中成药2025，Vol.47Issue(5)：1443-1448,6.DOI:10.3969/j.issn.1001-1528.2025.05.005
黄酒类型和酒制方法对当归化学成分、抗凝血作用的影响
Effects of rice wine type and wine processing method on chemical constituents and anti-coagulation effect of Angelicae sinensis Radix
摘要
Abstract
AIM To investigate the effects of rice wine type and wine processing method on chemical constituents and anti-coagulation effect of Angelicae sinensis Radix.METHODS Wine-washed products and wine-stir-fried products were prepared by different types and ages of rice wine,respectively,after which HPLC was adopted in the content determination of tryptophan,chlorogenic acid,vanillic acid,phthalic acid,ferulic acid,senkyunolide I,senkyunolide H,coniferyl ferulate and ligustilide,and PT,APTT,TT were detected in rabbit plasma.RESULTS Phenolic acids and volatile constituents demonstrated lower contents in the wine-stir-fried products than those in the raw product(P＜0.05),while those in the wine-washed products displayed no obvious changes(except for senkyunolide I)(P＞0.05).The contents of volatile constituents in the wine-washed products were higher than those in the wine-stir-fried products(P＜0.05).After being processed with dry rice wine,various constituents exhibited increased contents as compared with those after being processed with sweet rice wine(P＜0.05).Compared with the raw product,prolonged PT,APTT and TT were observable in the processed products prepared by 3-year semi-dry rice wine(P＜0.05).CONCLUSION The optimal rice wine type is determined to be 3-year semi-dry.Wine-washed Angelicae sinensis Radix shows high contents of ferulic acid and volatile constituents,whose activating blood and resolving stasis effect may be stronger.关键词
当归/黄酒/类型/酒制方法/化学成分/抗凝血作用/HPLCKey words
Angelicae sinensis Radix/rice wine/type/wine processing method/chemical constituents/anti-coagulation effect/HPLC分类
中医学引用本文复制引用
王颖,邓雅依,葛雪琪,朱慧,段煜,闫晓宁,蔡皓,裴科..黄酒类型和酒制方法对当归化学成分、抗凝血作用的影响[J].中成药,2025,47(5):1443-1448,6.基金项目
分子中医药学国际联合研究中心开放课题基金资助项目(2022JD-KF-01) （2022JD-KF-01）
山西省科技创新人才团队项目(202304051001044) （202304051001044）
山西省中医药管理局项目(2023ZYYA033) （2023ZYYA033）
山西中医药大学科研项目(2022PY-TH-13) （2022PY-TH-13）
