中国医院用药评价与分析2025，Vol.25Issue(5)：619-623,5.DOI:10.14009/j.issn.1672-2124.2025.05.022
咪达唑仑注射液致过敏反应的文献分析
Literature Analysis of Allergic Reactions Caused by Midazolam Injection
摘要
Abstract
OBJECTIVE:To investigate the clinical characteristics of allergic reactions caused by midazolam injection,and provide reference for safe medication in clinic.METHODS:By searching PubMed,Wanfang Data and CNKI(databases were established until Sept.2024),case reports of allergic reactions caused by midazolam injection were collected,and patients'gender,age,body mass,basic diseases/current medical history,reasons for medication,dosage,drug combination,time of allergic reaction occurrence,clinical manifestations,and prognosis were analyzed statistically.RESULTS:A total of 17 independent case reports were retrieved,including 21 patients,with 12 males and 9 females.There were 16 patients(76.19%)aged from>18 to 60 years.The single dosage of midazolam injection was from 1 mg to 10 mg.Totally 15 patients began to experience allergic reactions<30 minutes after the first medication,and 3 patients had allergic reactions≥30 minutes after the first medication.The symptoms of allergic reactions were skin urticaria,erythema,edema,and hypotension,and severe cases were bronchial spasm and anaphylactic shock.Thirteen patients had severe allergic reactions that were life-threatening or resulted in prolonged length of stay.Totally 19 patients were treated with midazolam injection only once and were in remission or returned to normal after 15 min to 2 d of symptomatic treatment.CONCLUSIONS:There are few reports of allergic reactions related to midazolam injection,yet the consequences are severe and should be paid attention to.关键词
咪达唑仑注射液/过敏反应/药品不良反应/文献分析Key words
Midazolam injection/Allergic reactions/Adverse drug reaction/Literature analysis分类
医药卫生引用本文复制引用
赵慧,姜紫薇,任爽,张宇,张威..咪达唑仑注射液致过敏反应的文献分析[J].中国医院用药评价与分析,2025,25(5):619-623,5.基金项目
首都卫生发展科研专项项目(No.首发2024-2-2077) （No.首发2024-2-2077）
