中国中医药信息杂志2025，Vol.32Issue(6)：24-28,5.DOI:10.19879/j.cnki.1005-5304.202405071
基于中西医临床病症特点的肝硬化动物模型分析
Analysis on Animal Model of Liver Cirrhosis Based on Clinical Symptoms in Characteristics Traditional Chinese and Western Medicine
摘要
Abstract
The potential pathogenesis of liver cirrhosis and the efficacy mechanism of TCM have not been elucidated yet.This article analyzed the characteristics of animal models of liver cirrhosis based on the diagnosis and treatment standards of traditional Chinese and Western medicine,providing reference for the study of disease syndrome integration.Relevant literature about animal models of liver cirrhosis was collected.Based on the diagnostic guidelines of Western medicine and the consensus of diagnosis and treatment of TCM,the evaluation indexes of models were established,and the clinical coincidence of animal models was analyzed.The results showed that the highest degree of Western medicine anastomosis was induced by ethanol,and the model induced by CCl4,TAA and DEN had a high degree of clinical anastomosis in TCM,which could be identified as liver stagnation and spleen deficiency syndrome.The existing animal models of liver cirrhosis can comprehensively imitate the mechanism and process of Western medicine disease,and can not meet the needs of both TCM syndrome and disease pathology.关键词
肝硬化/动物模型/中西医结合/分析评价Key words
cirrhosis/animal model/integration of traditional Chinese and Western medicine/analysis evaluation分类
医药卫生引用本文复制引用
赵静涵,朱正望,王琳琳,朱平生,苗明三..基于中西医临床病症特点的肝硬化动物模型分析[J].中国中医药信息杂志,2025,32(6):24-28,5.基金项目
国家自然科学基金(82074340) （82074340）
河南省科技创新人才计划-杰出青年项目(154100510020) （154100510020）
中医药传承与创新"百千万"人才工程(岐黄工程)岐黄学者-国家中医药领军人才支持计划(2022年) （岐黄工程）
