中国医院用药评价与分析2025，Vol.25Issue(5)：632-636,640,6.DOI:10.14009/j.issn.1672-2124.2025.05.025
槲皮素防治肝细胞癌相关信号通路研究进展
Progress of Signaling Pathways Related to Quercetin in the Prevention and Treatment of Hepatocellular Carcinoma
摘要
Abstract
Hepatocellular carcinoma(HCC)is the sixth most common malignant tumor in the world.It has the characteristics of high incidence,high malignancy and poor prognosis,which poses a serious threat to people's life and health.At present,the main treatment for HCC include surgical resection,drug therapy and interventional therapy.However,all these treatment methods have certain adverse drug reactions.Recent studies have confirmed that quercetin has a good anti-HCC effect.By reviewing the relevant literature on signaling pathways of quercetin in the prevention and treatment of HCC at home and abroad in recent years,this thesis found that quercetin can inhibit the growth,proliferation,metastasis and angiogenesis of HCC by regulating multiple signaling pathways such as Wnt/β-catenin,PI3K/Akt,MAPK,p53,JAK/STAT.It has multiple effects such as reversing precancerous lesions and multi-drug resistance of liver cancer,and inducing cell cycle arrest and apoptosis of tumor cells,with significant anti-tumor effects.By introducing the mechanism of quercetin mediated HCC-related signaling pathways,this thesis provides a theoretical basis for the development of new anti-tumor drugs.关键词
肝细胞癌/槲皮素/信号通路/作用机制/研究现状Key words
Hepatocellular carcinoma/Quercetin/Signaling pathways/Mechanism/Research progress分类
医药卫生引用本文复制引用
姚三飞,刘江凯..槲皮素防治肝细胞癌相关信号通路研究进展[J].中国医院用药评价与分析,2025,25(5):632-636,640,6.基金项目
河南省特色骨干学科中医学学科建设项目(No.STG-ZYX04-202133) （No.STG-ZYX04-202133）
河南省卫生健康委河南省中医药科学研究专项课题(No.2021JDZY003,No.2023ZY2007) （No.2021JDZY003,No.2023ZY2007）
