中国中医急症2025，Vol.34Issue(5)：791-795,5.DOI:10.3969/j.issn.1004-745X.2025.05.009
优化炎调方治疗急性呼吸窘迫综合征(肺热腑实证)的临床研究
Clinical Study on the Optimization Yantiao Decoction in Treating Acute Respiratory Distress Syndrome(Syndrome of Excessive Fu-viscera Caused by Lung-heat)
摘要
Abstract
Objective:To observe the clinical efficacy of Optimized Yantiao Decoction in treating adult acute re-spiratory distress syndrome(ARDS)with syndrome of excessive fu-viscera caused by lung-heat.Methods:A to-tal of 112 patients were randomly divided into a treatment group and a control group.Both groups received stan-dard western medical treatment.The treatment group was added with Optimized Yantiao Decoction,while the con-trol group received a placebo.The course of treatment lasted for 7 days,with a follow-up of 28 days.Clinical effi-cacy was evaluated by comparing the 28 day cumulative survival rate,total TCM syndrome score,APACHE Ⅱscore,oxygenation indicators(SpO2,PaO2,PaCO2,PaO2/FiO2),perfusion indicators(Lac),inflammatory markers(WBC,PCT,CRP,IL-6),and duration of continuous mechanical ventilation between the two groups.Drug safety was assessed by monitoring basic vital signs,liver and kidney function,electrocardiogram,and routine stool and urine tests.Results:A total of 105 patients completed the study.After 28 days of follow-up,the treatment group had a higher 28 day cumulative survival rate and overall clinical efficacy compared with in the control group(both P＜0.05).The total TCM syndrome scores in both groups decreased after treatment,with the treatment group show-ing better results(P＜0.05).Oxygenation indicators(SpO2,PaO2,PaO2/FiO2)improved in both groups after treat-ment,with the treatment group showing better results(P＜0.05).The APACHE Ⅱ scores,Lac,WBC,CRP,IL-6,and PCT decreased in both groups after treatment,with the treatment group showing lower values(P＜0.05).After treatment,PaCO2 in both groups was significantly lower than that before treatment(P＜0.05).However,there was no significant difference in PaCO2 in both groups after treatment(P＞0.05).The duration of continuous mechanical ventilation was shorter in the treatment group(P＜0.05).There were no significant abnormalities in safety indica-tors before and after treatment in both groups.Conclusion:The combination of Optimized Yantiao Decoction and standard western medical treatment can reduce inflammation,improve oxygenation,shorten the duration of continu-ous mechanical ventilation,and increase the 28 day cumulative survival rate in ARDS patients with syndrome of excessive fu-viscera caused by lung-heat,which is clinically effective and safe.关键词
急性呼吸窘迫综合征/优化炎调方/肺热腑实证Key words
Acute respiratory distress syndrome/Optimized Yantiao Decoction/Syndrome of excessive fu-vis-cera caused by lung-heat分类
医药卫生引用本文复制引用
徐童,金源源,郑佳萍,严佳,陈天阳,韩丹,诸炳骅,王倩..优化炎调方治疗急性呼吸窘迫综合征(肺热腑实证)的临床研究[J].中国中医急症,2025,34(5):791-795,5.基金项目
国家自然科学基金项目(82074156) （82074156）
上海市科学技术委员会"科技创新行动计划"医学创新研究专项项目(20Y21900300) （20Y21900300）
上海申康医院发展中心临床科技创新项目(SHDC22021203) （SHDC22021203）
