中成药2025，Vol.47Issue(5)：1514-1519,6.DOI:10.3969/j.issn.1001-1528.2025.05.015
黑骨藤追风活络胶囊联合结筋病灶点温针灸对寒湿痹阻型膝骨关节炎患者的临床疗效
Clinical effects of Heiguteng Zhuifeng Huoluo Capsules combined with warm acupuncture at musculotendinous pathological nodes on patients with knee osteoarthritis due to Cold-Dampness Obstruction and Fixed Impediment
摘要
Abstract
AIM To explore the clinical effects of Heiguteng Zhuifeng Huoluo Capsules combined with warm acupuncture at musculotendinous pathological nodes on patients with knee osteoarthritis due to Cold-Dampness Obstruction and Fixed Impediment.METHODS One hundred and sixty patients were randomly assigned into control group(80 cases)for 4-week intervention of both warm acupuncture at musculotendinous pathological nodes and Celecoxib Capsules,and observation group(80 cases)for 4-week intervention of Heiguteng Zhuifeng Huoluo Capsules,warm acupuncture at musculotendinous pathological nodes and Celecoxib Capsules.The changes in clinical effects,TCM syndrome scores,WOMAC scores,Lequesne indices,pain mediators(PGE2,β-EP),growth factors(TGF-β1,IGF-1),bone metabolism indices(OPG,RANKL),TLR4/NF-κB signaling pathway and safety indices were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,WOMAC scores,Lequesne indices,PGE2,RANKLE,TLR4,NF-κB(P＜0.05),and increased β-EP,growth factors,OPG(P＜0.05),especially for the observation group(P＜0.05).No serious adverse events or reactions were observable in the two groups.CONCLUSION For the patients with knee osteoarthritis due to Cold-Dampness Obstruction and Fixed Impediment,Heiguteng Zhuifeng Huoluo Capsules combined with warm acupuncture at musculotendinous pathological nodes can safely and effectively alleviate clinical symptoms,improve knee joint pain,and enhance joint functions,whose action mechanisms may contribute to the inhibition of TLR4/NF-κB signaling pathway expression and regulations of serum TGF-β1,IGF-1,OPG,RANKL levels.关键词
黑骨藤追风活络胶囊/温针灸/结筋病灶点/塞来昔布胶囊/膝骨关节炎/寒湿痹阻Key words
Heiguteng Zhuifeng Huoluo Capsules/warm acupuncture/musculotendinous pathological nodes/Celecoxib Capsules/knee osteoarthritis/Cold-Dampness Obstruction and Fixed Impediment分类
医药卫生引用本文复制引用
但晶,丁华,王刚,王家豪,巨少华,路怀民..黑骨藤追风活络胶囊联合结筋病灶点温针灸对寒湿痹阻型膝骨关节炎患者的临床疗效[J].中成药,2025,47(5):1514-1519,6.基金项目
四川省自然科学基金项目(2023NSFSC1803) （2023NSFSC1803）
