中国中医急症2025，Vol.34Issue(5)：796-799,4.DOI:10.3969/j.issn.1004-745X.2025.05.010
急性脑梗死患者临床-弥散不匹配与中医证候的关系及对预后结局的影响研究
Relationship Between Clinical-diffusion Mismatch and Traditional Chinese Medicine Syndrome in Patients with Acute Cerebral Infarction and Its Impact on Prognosis
摘要
Abstract
Objective:To study deepen previous research findings by tracking the dynamic changes in clinical-diffusion mismatch(CDM)within one week after acute cerebral infarction,and to further explore its relationship with TCM syndromes and prognosis.Methods:A total of 336 patients with acute cerebral infarction who were ad-mitted within 72 hours of onset were included in this study.All patients underwent cranial MRI examination with-in one week of onset.Based on the criteria for CDM,i.e.,NIHSS score not less than 8 points and DWI-Alberta Stroke Program Early CT Score(ASPECTS)not less than 8 points,patients were divided into a CDM group(96 cas-es)and a non-CDM group(240 cases).The NIHSS scores,mRS scores,and TCM syndrome evaluations were con-ducted at admission,7,15,and 30 d.Results:The CDM group showed more significant reductions in NIHSS scores at 7,15,and 30 d after admission,with better neurological outcomes compared with the non-CDM group.Early TCM syndromes were mainly characterized by wind syndrome and blood stasis,which evolved over time with reductions in wind syndrome,phlegm syndrome,and blood stasis,while qi deficiency symptoms improved.In the CDM group,changes in mRS scores were negatively correlated with antiplatelet aggregation therapy,whereas in the non-CDM group,they were negatively correlated with promoting blood circulation and removing blood stasis thera-py.Conclusion:Within one week of onset,there is still potential for salvaging brain tissue in patients with acute cerebral infarction.Patients with CDM have a more favorable neurological prognosis.The main TCM syndrome manifestations include transitions from blood stasis and qi deficiency.For patients with CDM,treatment tends more towards antiplatelet aggregation,while for those without CDM,emphasis is placed on promoting blood circula-tion and removing blood stasis.关键词
急性脑梗死/临床-弥散不匹配/中医证候/临床结局/治疗策略Key words
Acute cerebral infarction/Clinical-diffusion mismatch/TCM syndrome/Clinical outcome/Treatment strategy分类
医药卫生引用本文复制引用
胡杰,许瑞卿,吕祥龙,王亚伟..急性脑梗死患者临床-弥散不匹配与中医证候的关系及对预后结局的影响研究[J].中国中医急症,2025,34(5):796-799,4.基金项目
安徽省中医药传承创新科研项目(2020ccyb27) （2020ccyb27）
滁州市科技计划项目(2021ZD028) （2021ZD028）
