中国心理卫生杂志2025，Vol.39Issue(6)：477-482,6.DOI:10.3969/j.issn.1000-6729.2025.06.01
精神分裂症患者非周期性脑电信号与认知功能的相关性
Disrupted aperiodic neural activity and differential cognitive correlates in patients with schizophrenia
摘要
Abstract
Objective:To explore the aperiodic components(1/f slopes)and their associations with cognitive impairment in patients with schizophrenia.Methods:Nineteen patients with schizophrenia according to the Interna-tional Statistical Classification of Diseases and Related Health Problem,Tenth Revision(ICD-10)and 21 normal controls were administrated the total Brief Assessment of Cognition in Schizophrenia(BACS)to measure the cogni-tive performance.The 5-minute eyes-closed and eyes-open resting EEG signals were collected and parameterized in-to aperiodic components(1/f slope).Finally,Pearson correlation was used to examine the relationships between the 1/f slope and cognition assessment scores.Results:The patients with schizophrenia had higher 1/f slope compared to HC on central location of scalp(P＜0.05).The vocal memory scores showed a significantly positive relation with 1/f slopes in patients with schizophrenia(anterior location:r=-0.68,P＜0.05;central location:r=-0.44,P＜0.05),but a significantly negative relation in normal controls(anterior location:r=0.57,P＜0.05;posterior lo-cation:r=0.54,P＜0.05).Conclusion:The 1/f slopes of EEG in schizophrenia were steeper than normal control,suggesting its strong cognitive functional significance and complex mechanisms in schizophrenia.关键词
精神分裂症/认知功能/脑电图/功率谱密度/1/f斜率Key words
schizophrenia/cognitive performance/electroencephalography/power spectral density/1/f slope分类
临床医学引用本文复制引用
张可心,袁艺琳,周天航,伍庭芳,杜春雨,谢晨妹,陈蔚然,王婧,于欣..精神分裂症患者非周期性脑电信号与认知功能的相关性[J].中国心理卫生杂志,2025,39(6):477-482,6.基金项目
国家自然科学基金"首发难治性精神分裂症的精准识别和治疗新思路"(82171500),国家自然科学基金"早发精神分裂症基因组罕见变异的鉴定与致病机制研究"(32070589) （82171500）
