摘要
Abstract
Objective:To investigate the interplay between childhood traumatic experiences,mental disorders,and cognitive function among patients with alcohol use disorder(AUD).Methods:A cross-sectional study was con-ducted involving 160 patients with AUD hospitalized in the department of alcohol dependence.They were catego-rized into three groups based on their symptoms,namely the simple alcohol dependence group(AD group,n=86),the alcohol dependence with hallucinatory delusion group(ADHD group,n=43),and the alcohol dependence with delirium tremens group(ADDT group,n=31).The adverse childhood experiences,cognitive function,and child-hood trauma were assessed with the Adverse Childhood Experiences International Questionnaire(ACE-IQ),Mont-real Cognitive Assessment(MoCA),and Childhood Trauma Questionnaire(CTQ-SF).Results:The MoCA scores were significantly higher in the AD group than in the ADHD and ADDT groups[21.0(19.0,23.0)vs.19.0(15.0,22.0)vs.18.0(16.0,22.0),P＜0.01].The ADDT group had higher sexual abuse scores of CTQ-SF than the AD group.Lower MoCA score was associated with hallucination and delusion(OR=0.82,P＜0.01)or deliri-um tremens(OR=0.81,P＜0.01)in AUD patients.Higher ACE-IQ score was associated with hallucination and delusion in AUD patients(OR=1.51,P＜0.01).Conclusion:Mostpatients with alcohol use disorder have child-hood trauma and cognitive dysfunction.Poor cognitive function and adverse childhood experiences are risk factors for mental disorders among patients with alcohol use disorder.关键词
酒精使用障碍/童年创伤/认知功能/震颤谵妄/幻觉妄想Key words
alcohol use disorder/childhood trauma/cognitive function/delirium tremens/hallucinatory de-lusion分类
临床医学
