中国中医药信息杂志2025，Vol.32Issue(6)：147-152,6.DOI:10.19879/j.cnki.1005-5304.202412511
益气生津散联合西医常规疗法治疗糖尿病性心脏病效果及对患者心脏自主神经功能、心功能、炎症因子的影响
Efficacy of Yiqi Shengjin Powder Combined with Convectional Western Medicine on Diabetic Heart Disease and Its Effects on Cardiac Autonomic Nervous Function,Cardiac Function and Inflammatory Factors
摘要
Abstract
Objective To observe the clinical efficacy of Yiqi Shengjin Powder combined with conventional Western medicine in the treatment of diabetic heart disease,and the effects on cardiac autonomic nervous function,cardiac function and inflammatory factors.Methods Totolly 84 patients with diabetic heart disease were divided into control group and treatment group with random number table method,with 42 cases in each group.The control group developed personalized hypoglycemic plans and heart disease treatment drugs based on the patients'blood glucose levels.The treatment group took Yiqi Shengjin Powder in addition to the control group,and after an interval of 0.5 hours with Western medicine,they took it with warm water,2 bags each time,twice a day,for 6 consecutive weeks of treatment.TCM therapeutic effects of two groups,TCM symptoms score,sinus rhythm RR interval(SDNN),root mean square of adjacent interval difference(RMSSD),standard deviation of RR interval mean(SDANN),high frequency(HF),low frequency(LF),various indicators of cardiac function[left ventricular ejection fraction(LVEF),left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD)],inflammatory factors[interleukin-6(IL-6),transforming growth factor beta 1(TGF-β1),tumor necrosis factor alpha(TNF-α)]and adverse reactions before and after treatment were observed.Results The total effective rate of the treatment group was 90.48%(38/42),while that of the control group was 73.81%(31/42).The therapeutic effect of the treatment group was better than that of the control group(P<0.05).Compared with before treatment,both group showed a significant decrease in chest pain,tightness,palpitations,palpitations and shortness of breath,excessive dreaming and sweating,five heart restlessness and fatigue scores after treatment(P<0.05);after treatment,the treatment group showed a decrease in chest pain,tightness,palpitations,palpitations and shortness of breath,excessive dreaming and sweating,five heart restlessness and fatigue scores compared to the control group(P<0.05).Compared with before treatment,both group showed a significant increase in SDNN,SDANN,RMSSD,HF and LF after treatment(P<0.05);after treatment,the SDNN,SDANN,RMSSD,HF and LF levels in the treatment group were significantly higher than those in the control group(P<0.001).Compared with before treatment,LVEF increased,LVEDD and LVESD decreased in both group after treatment(P<0.001);after treatment,the LVEF of the treatment group increased compared to the control group,while LVEDD and LVESD decreased compared to the control group(P<0.001).Compared with before treatment,the serum levels of TNF-α,TGF-β1 and IL-6 in both groups decreased(P<0.001);after treatment,the serum levels of TNF-α,TGF-β1 and IL-6 in the treatment group were lower than those in the control group(P<0.001).There was no statistical significance in adverse reactions between the two groups(P>0.05).Conclusion Yiqi Shengjin Powder combined with conventional Western medicine therapy for patients with diabetes heart disease has significant effect and high safety.It can effectively improve patients'cardiac autonomic nervous function and cardiac function,reduce inflammatory reaction,and has no serious adverse reactions.关键词
糖尿病性心脏病/益气生津散/心脏自主神经功能/心功能/炎症反应Key words
diabetic heart disease/Yiqi Shengjin Powder/cardiac autonomic nervous function/heart function/inflammatory response分类
医药卫生引用本文复制引用
翟军鹏,李江敏子,尚菊菊,张竹华..益气生津散联合西医常规疗法治疗糖尿病性心脏病效果及对患者心脏自主神经功能、心功能、炎症因子的影响[J].中国中医药信息杂志,2025,32(6):147-152,6.基金项目
北京市属医院科研培育计划项目(PZ2022023) （PZ2022023）
