中国现代医生2025，Vol.63Issue(13)：5-9,5.DOI:10.3969/j.issn.1673-9701.2025.13.002
Gd-EOB-DTPA增强MRI影像组学预测肝细胞癌组织病理学分级的价值
The value of Gd-EOB-DTPA enhanced MRI radiomics in predicting the histopathological grading of hepatocellular carcinoma
摘要
Abstract
Objective To investigate the value of enhanced magnetic resonance imaging(MRI)radiomics based on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid(Gd-EOB-DTPA)in predicting the histopathological grading of hepatocellular carcinoma(HCC)before surgery.Methods A total of 101 patients with HCC who were treated in the Second Affiliated Hospital of Kunming Medical University from January 2021 to June 2024 were selected as study subjects and randomly assigned to the training set(n=70)and the test set(n=31)in a ratio of 7∶3.Radiomics features were extracted from portal venous phase(PVP)and hepatobiliary phase(HBP)images,and support vector machine(SVM)image omics model was constructed after dimensionality reduction by least absolute shrinkage and selection operator logistic regression.Model performance was assessed by area under the curve(AUC),accuracy,sensitivity,and specificity.Results After feature screening,the SVM model was constructed by retaining the best image omics features of 2 HBP,5 PVP and 11 combined models.The AUC of PVP,HBP and PVP+HBP combined models were 0.870,0.914 and 0.952,respectively,showing a good ability to distinguish between high and low grade HCC.Conclusion Compared with the independent model,PVP+HBP combined model has better performance in predicting HCC histopathological grading,and can be used as a non-invasive auxiliary tool to help distinguish between high-grade and low-grade HCC before surgery.关键词
肝细胞癌/钆塞酸二钠/增强磁共振成像/组织病理学分级/影像组学Key words
Hepatocellular carcinoma/Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid/Enhanced magnetic resonance imaging/Histopathological grading/Radiomics分类
临床医学引用本文复制引用
吕潇潇,李志丽,董慧敏,郭立..Gd-EOB-DTPA增强MRI影像组学预测肝细胞癌组织病理学分级的价值[J].中国现代医生,2025,63(13):5-9,5.基金项目
云南省卫生健康委员会医学学科带头人培养计划项目(D-2019024) （D-2019024）
