中国现代医生2025，Vol.63Issue(13)：33-36,4.DOI:10.3969/j.issn.1673-9701.2025.13.008
血液肿瘤患者自体造血干细胞动员相关因素及血小板计数预测价值研究
Study on the correlation factors of autologous hematopoietic stem cell mobilization and the predictive value of platelet counts in patients with hematologic tumors
陈丽 1赵明哲 1朱亭郡 1夏冰天 1李璐璐1
作者信息
- 1. 浙江大学医学院附属金华医院血液科,浙江金华 321000
- 折叠
摘要
Abstract
Objective To analyze the factors influencing the mobilization and collection of peripheral blood hematopoietic stem cells in patients with hematologic tumors,and to explore the predictive value of platelet counts in the process of autologous stem cell collection.Methods A total of 52 patients with hematologic tumors who underwent autologous hematopoietic stem cell transplantation in Affiliated Jinhua Hospital,Zhejiang University School of Medicine from September 2018 to March 2024 were selected.Binary Logistic regression analysis was used to explore the influencing factors of peripheral blood stem cell collection,and receiver operating characteristic(ROC)curve was used to determine the optimal cut-off value of platelet counts before collection.Results Among the 52 patients,36 patients had high-quality mobilization and 16 patients had non-high-quality mobilization.The number of chemotherapy cycles before collection and mobilization plan had significant effects on the number of CD34+cells collected,while age,gender,collection machine,and bone marrow involvement had no significant effects on the number of CD34+cells collected.The platelet counts in high-quality mobilization group were significantly higher than those in non-high-quality mobilization group(P＜0.05).Binary Logistic regression analysis showed that platelet counts before collection had a significant effect on the collection of peripheral blood stem cells(OR=0.975,95％CI:0.954-0.997,P=0.025).ROC curve results showed that the area under the curve of platelet counts prediction of stem cell quality collection was 0.732,the optimal cut-off value was 86×109/L,the sensitivity was 72.2％,and the specificity was 81.2％.Subgroup analysis showed that platelet transfusion had no significant effect on the number of CD34+cells.Conclusion The number of chemotherapy cycles before collection and mobilization plan can affect the number of autologous hematopoietic stem cells.The platelet counts before collection can help determine the best time for collection and improve the success rate of collection.关键词
血液肿瘤/造血干细胞移植/血小板Key words
Hematologic tumor/Hematopoietic stem cell transplantation/Platelet分类
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陈丽,赵明哲,朱亭郡,夏冰天,李璐璐..血液肿瘤患者自体造血干细胞动员相关因素及血小板计数预测价值研究[J].中国现代医生,2025,63(13):33-36,4.
