中山大学学报（自然科学版）（中英文）2025，Vol.64Issue(3)：1-11,11.DOI:10.13471/j.cnki.acta.snus.ZR20240314
圆叶乌桕的化学成分
The chemical constituents of Triadica rotundifolia
摘要
Abstract
In this study,a total of 23 compounds were obtained from the ethyl acetate part of Triadica rotundifolia by various chromatographic methods such as silica gel,Sephadex LH20,and p-HPLC column chromatography.Their structures were identified by NMR spectroscopy combined with comparative analysis with literature data as known compounds:toddanone(1),toddalolactone(2),scopoletin(3),6,7-dimethoxycoumarin(4),6,7,8-trimethoxycoumarin(5),8-hydroxy-5,6,7-trimethoxycoumarin(6),5,6,7,8-tetramethoxycoumarin(7),lup-20(29)-ene-3α,23-diol(8),glochidone(9),3β-O-trans-caffeoylbetulinic acid(10),oleana-1,18-dien-3-one(11),morolic acid acetate(12),β-sitosterol(13),daucosterol(14),6-hydroxystigmast-4-en-3-one(15),oleodaphnone(16),5′-methoxynobiletin(17),trigonochinene E(18),ethyl gallate(19),daphnelantoxin B(20),(+)-3-hydroxy-1,5-diphenyl-l-pentanone(21),5-hydroxy-3,4-dimethyl-5-pentylfuran-2(5H)-one(22),and indole-3-carbaldehyde(23).Compounds 1-23 were isolated from T.rotundifolia for the first time.In addition,activity screening revealed that compounds 8 and 18 showed moderate cytotoxicity to H1975 cells,with IC50 values of(13.97±0.40)μmol/L and(26.61±1.81)μmol/L,respectively.关键词
圆叶乌桕(Triadica rotundifolia)/化学成分/细胞毒Key words
Triadica rotundifolia/chemical constituents/cytotoxicity分类
化学引用本文复制引用
陈佳倩,崔清雅,吴雷名,陈贤安,郑冰莹,黄冬,唐贵华..圆叶乌桕的化学成分[J].中山大学学报（自然科学版）（中英文）,2025,64(3):1-11,11.基金项目
广州市科技计划项目(2024B03J1322) （2024B03J1322）
广东省科技计划项目(2023A1111120025) （2023A1111120025）
