中山大学学报（自然科学版）（中英文）2025，Vol.64Issue(3)：12-18,7.DOI:10.13471/j.cnki.acta.snus.ZR20240327
桶状海绵共生真菌Penicillium rolfsii 8196#次级代谢产物
The secondary metabolites of the marine-derived fungus Penicillium rolfsii 8196 isolate from sponge Xestospongia sp.
摘要
Abstract
Nine known aromatic compounds(1-9)were isolated from the ethyl acetate extracts of the solid cultures of marie-derived fungus Penicillium rolfsii 8196#,isolated from sponge xestospongia sp..Their structures were elucidated by spectroscopic analysis and comparative investigation with references.These compounds were evaluated for their cytotoxic,antibacterial and antioxidant activities.Among them,Compound 6 showed cytotoxicity against human bladder cancer T-24 cells with the IC50 values of 16.60 μmol/L,compounds 4 and 5 exhibited weak inhibitory effects against Salmonella with MIC values of 50 μmol/L,and compounds 8 and 9 showed the free radical scavenging rate 79.81%and 70.84%at the concentration of 10 μmol/L,respectively.关键词
海绵共附生真菌/青霉属/次级代谢产物Key words
marine-derived fungus/Penicillium sp./secondary metabolites分类
化学引用本文复制引用
郑娜妹,刘洪亮,唐凤婷,李锦俊,张轩,杜志云,黄华容,刘岚..桶状海绵共生真菌Penicillium rolfsii 8196#次级代谢产物[J].中山大学学报（自然科学版）（中英文）,2025,64(3):12-18,7.基金项目
教育部省部共建药用资源化学与药物分子工程国家重点实验室开放基金(CMEMR2022-B03) （CMEMR2022-B03）
