中山大学学报（自然科学版）（中英文）2025，Vol.64Issue(3)：19-25,7.DOI:10.13471/j.cnki.acta.snus.ZR20240228
南海表层真菌Aspergillus versicolor NJF3的次生代谢产物
The secondary metabolites from a South China Sea surface fungi Aspergillus versicolor NJF3
摘要
Abstract
The secondary metabolites of the rice fermentation of Aspergillus versicolor NJF3,a fungus derived from the surface seawater of the South China Sea,were investigated in this study.The rice solid fermentation product of this strain was extracted with 95%ethanol and subjected to ethyl acetate extraction,followed by repeated chromatographic separation and purification.As a result,a total of 15 compounds were obtained,and their structures were identified by spectral data analysis as meleagrin(1),fumigaclavine C(2),cyclo(L-Trp-L-Phe)(3),phenazine-1-carboxylic acid(4),phenazine-1-carboxamide(5),N-(2-hydroxypropanoyl)-2-aminobenzoic acid amide(6),orlandin(7),monomethylsulochrin(8),sydowinin A(9),diorcinol-3-O-α-D-ribofuranoside(10),cordyol C-3-O-α-D-ribofuranoside(11),3,3'-dihydroxy-5,5'-dimethyldiphenyl ether(12),3,5-dihydroxytoluene(13),3,7-dihydroxy-1,9-dimethyldibenzofuran(14),and p-hydroxyphenylacetic acid methyl ester(15),respectively.All compounds were known structures,among them diphenyl ether glycosides 10 and 11 were isolated from secondary metabolites of A.variegatus for the first time.In addition,activity screening showed that compound 1 moderate cytotoxicity to NSCLC cells.关键词
海洋真菌/次级代谢产物/曲霉/细胞毒Key words
marine fungi/secondary metabolites/Aspergillus/cytotoxicity分类
化学引用本文复制引用
卢清仁,吴雷名,翁汉桩,唐贵华..南海表层真菌Aspergillus versicolor NJF3的次生代谢产物[J].中山大学学报（自然科学版）（中英文）,2025,64(3):19-25,7.基金项目
南方海洋科学与工程广东省实验室(珠海)自主科研项目(SML2021SP301) （珠海）
