中山大学学报（自然科学版）（中英文）2025，Vol.64Issue(3)：36-46,11.DOI:10.13471/j.cnki.acta.snus.ZR20240343
桉属植物细叶桉Eucalyptus tereticornis的化学成分
Chemical constituents from Eucalyptus tereticornis of genus Eucalyptus
摘要
Abstract
To study the chemical constituents of the Eucalyptus tereticornis and explore their potential biological activity,a total of 21 compounds were obtained from the petroleum ether and ethyl acetate part of the ethanol extract of Eucalyptus tereticornis by silica gel column chromatography,Sephadex LH-20 column chromatography,and semi-preparative high performance liquid chromatography(HPLC).By the analysis of NMR,ESI-MS,and specific rotation values combined with comparative analysis with literature data,the structures of compounds were identified as ten lignans:Ehletianol C(1),dihydrobuddlenol B(2),dehydrodiconiferyl alcohol(3),herpetin(4),vitrifol A(5),(-)-syringaresinol(6),(-)-lyoniresinol(7),(-)-isolariciresinol(8),erythro-1-(3,4-dimethoxyphenyl)-2-O-(2-methoxy-4-omegahydroxypropylphenyl)propane-1,3-diol(9),and threo-guaiacylglycerol-β-O-4′-dihydroconiferyl alcohol(10);three phloroglucinols:multifidol glucoside(11),lysidiside A(12),and 2,4,6-trihydroxy-1-butyrophenone-2-O-β-D-glucopyranoside(13);three flavones:(S)-naringenin 7-O-glycoside(14),(-)-2,3-trans-dihydrokeampferol-3-O-α-L-rhamnoside(15),and phloretin(16);and five aryl C-glycosides:garcimangosone D(17),deoxyrhaponticin(18),glochierioside F(19),citrusin C(20),and benzyl β-D-glucopyranoside(21).All the compounds were separated from Eucalyptus tereticornis for the first time,and compounds 1,2,4,5,19,and 20 were separated from the genus Eucalyptus for the first time.The in vitro antioxidant activity of compounds was evaluated by using DPPH method.The results indicated that compounds 1,4,6,7,9,10,12,13,15,and 16 exhibited certain activity,with IC50 values ranging from 13.42-65.97 μg/mL,weaker than vitamin C.Among them,compounds 3,6,and 10 showed significant antioxidant activity,comparable to vitamin C.关键词
细叶桉(Eucalyptus tereticornis)/间苯三酚/黄酮/木脂素/化学成分Key words
Eucalyptus tereticornis/phloroglucin/flavanonols/lignans/chemical constituents分类
中医学引用本文复制引用
薛俊娟,李波,王雷清,崔玉磊,廖琼..桉属植物细叶桉Eucalyptus tereticornis的化学成分[J].中山大学学报（自然科学版）（中英文）,2025,64(3):36-46,11.基金项目
国家自然科学基金(82204762) （82204762）
山东省中医药科技发展计划项目(2020M037) （2020M037）
