肿瘤防治研究2025，Vol.52Issue(5)：361-367,7.DOI:10.3971/j.issn.1000-8578.2025.24.1255
四跨膜蛋白在结直肠肿瘤中的研究进展
Research Advances in Tetraspanins in Colorectal Cancer
摘要
Abstract
The tetraspanins are closely associated with the development and therapeutic prognosis of colorectal tumors.These proteins play a role in cell proliferation,metastasis,and invasion,regulate apoptosis and autophagy of colorectal tumor cells.affect immune escape by releasing exosomes,intervening the epithelial-mesenchymal transition process,and altering the tumor microenvironment,and enhance tumor stemness through specific pathways.This paper reviews the mechanisms and current research regarding the status of tetraspanins in colorectal cancer,aiming to improve early diagnosis and providing valuable insights for treatment strategies.关键词
结直肠肿瘤/四跨膜蛋白/肿瘤微环境/免疫逃逸/靶向治疗Key words
Colorectal cancer/Tetraspanins/Tumor microenvironment/Immune escape/Targeted therapy分类
临床医学引用本文复制引用
刘成炜,王琨杨,胡震,李耀平..四跨膜蛋白在结直肠肿瘤中的研究进展[J].肿瘤防治研究,2025,52(5):361-367,7.基金项目
Key Project of Shanxi Medicine(No.2022XM25) （No.2022XM25）
Shanxi Province Basic Research Program(No.202103021224379) 山西医学重点科研项目(2022XM25) （No.202103021224379）
山西省基础研究计划(202103021224379) （202103021224379）
