血液生物标志物检测对晚期非小细胞肺癌EGFR-TKI治疗疗效的评估价值
Evaluation Value of Blood Biomarker Tests for Efficacy of EGFR-TKI in Advanced NSCLC Treatment
摘要
Abstract
Objective To analyze the levels of serum CTCs and ctDNA in NSCLC patients receiving first-line EGFR-TKI treatment,and to explore the clinical value of CTCs and ctDNA detection in assessing the efficacy of treatment for advanced lung cancer.Methods A total of 109 NSCLC patients receiving first-line EGFR-TKI treatment were enrolled.Serum tumor markers CEA,CTCs,and ctDNA were detected at baseline and after one month of treatment.Chest CT scans were performed,and treatment efficacy was evaluated based on RECIST1.1 criteria.CTCs were counted by enrichment-staining-computational algorithm to analyze malignant features,while ctDNA was assessed using digital PCR.Results Survival rate was low in patients with abnormal CEA and ctDNA tests at baseline and in patients with reduced serum CTCs after treatment.In the SD subgroup of patients with brain metastases and advanced stage,the PFS benefit was low.Conclusion Patients in the SD subgroup have significantly higher recurrence risks than those in the PR or CR subgroups.Therefore,CTC and ctDNA testing should be applied to patients in the SD subgroup to identify high-risk patients with poor response to EGFR-TKI treatment,intervene with additional treatment promptly,and obtain long progression-free survival.关键词
晚期非小细胞肺癌/EGFR-TKI/疗效/循环肿瘤细胞/循环肿瘤DNAKey words
Advanced NSCLC/EGFR-TKI/Efficacy/Circulating tumor cells/Circulating tumor DNA分类
临床医学引用本文复制引用
范瑞,吴勇汇,顾瞻,彭艳斌,王丽新..血液生物标志物检测对晚期非小细胞肺癌EGFR-TKI治疗疗效的评估价值[J].肿瘤防治研究,2025,52(5):382-387,6.基金项目
National Natural Science Foundation of China(No.82004115) （No.82004115）
Key Specialty Cultivation Project of Traditional Chinese Medicine Clinical Practice by the Shanghai Municipal Administration of Traditional Chinese Medicine(No.ZY2021-2023-0302) （No.ZY2021-2023-0302）
Special Project for Integrating Traditional Chinese and Western Medicine by the Shanghai Municipal Administration of Traditional Chinese Medicine(No.ZHYY-ZXYJHZX-202107) （No.ZHYY-ZXYJHZX-202107）
Shanghai Clinical Research Center of Traditional Chinese Medicine Oncology,Science and Technology Commission of Shanghai Municipality(No.21MC1930500) （No.21MC1930500）
Shanghai Municipal Health Commission Project(No.2022QN094) （No.2022QN094）
National Administration of Traditional Chinese Medicine Integration of Traditional Chinese and Western Medicine Flagship Department Construction Project （）
Shanghai Key Discipline of Traditional Chinese Medicine(No.shzyyzdxk-2024106) 国家自然科学基金(82004115) （No.shzyyzdxk-2024106）
上海市中医药管理局中医临床重点专科培育项目(ZY2021-2023-0302) （ZY2021-2023-0302）
上海市中医药管理局中西医结合专项(ZHYY-ZXYJHZX-202107) （ZHYY-ZXYJHZX-202107）
上海市中医肿瘤临床医学研究中心,上海市科学技术委员会项目(21MC1930500) （21MC1930500）
上海市卫生健康委员会项目(2022QN094) （2022QN094）
国家中医药管理局中西医协同旗舰科室建设项目 （）
上海市中医药临床重点学科(shzyyzdxk-2024106) （shzyyzdxk-2024106）
