肿瘤防治研究2025，Vol.52Issue(5)：393-399,7.DOI:10.3971/j.issn.1000-8578.2025.24.1254
YWHAQ表达与胃腺癌患者临床病理特征及预后的关系
Relationship Between YWHAQ Expression and Clinicopathological Features and Prognosis of Patients with Gastric Adenocarcinoma
摘要
Abstract
Objective To investigate the expression of YWHAQ protein in gastric adenocarcinoma tissues and its correlation with clinical pathological features and prognosis.Methods A total of 127 patients with gastric cancer who underwent radical surgery were enrolled.Clinical data and postoperative cancer tissue samples were collected from the patients.Immunohistochemistry was used to detect the protein expression of YWHAQ in gastric adenocarcinoma tissues.The relationship between YWHAQ expression and clinical pathological features and prognosis was analyzed.Bioinformatics prediction was performed to identify potential pathways regulated by YWHAQ in gastric adenocarcinoma.A protein-protein interaction network for YWHAQ was constructed using the STRING database.Results YWHAQ gene expression was significantly higher in gastric adenocarcinoma tissues than in normal tissues(P<0.05).The expression level of the YWHAQ protein was significantly correlated with age,tumor invasion depth,lymph node metastasis,and tumor stage(P<0.05).Kaplan-Meier survival analysis showed that patients with high YWHAQ expression had significantly poorer long-term survival than those with low expression(P<0.0001).Cox regression analysis revealed that high YWHAQ expression and distant metastasis were independent risk factors for gastric cancer(HR>1,P<0.05).Enrichment analysis indicated that YWHAQ positively regulated processes such as cell cycle,angiogenesis,and DNA damage repair.Conclusion YWHAQ is highly expressed in gastric adenocarcinoma tissues and may be associated with the occurrence,invasion,and metastasis of gastric adenocarcinoma.High YWHAQ expression and distant metastasis are independent risk factors for the prognosis of gastric adenocarcinoma patients.关键词
胃腺癌/YWHAQ/临床病理特征/预后Key words
Gastric adenocarcinoma/YWHAQ/Clinicopathologic features/Prognosis分类
临床医学引用本文复制引用
刘学晴,杨立波,李临海,盛萍,刘思呈,李丽华..YWHAQ表达与胃腺癌患者临床病理特征及预后的关系[J].肿瘤防治研究,2025,52(5):393-399,7.基金项目
Yunnan Province Ten Thousand Talents Program Famous Doctor Special Project(No.YNWR-MY-2020-006) （No.YNWR-MY-2020-006）
Science and Technology Plan Project of the First People's Hospital of Yunnan Province(No.2024-KHRCBZ-B03) 云南省万人计划名医专项(YNWR-MY-2020-006) （No.2024-KHRCBZ-B03）
云南省第一人民医院科技计划项目(2024-KHRCBZ-B03) （2024-KHRCBZ-B03）
