肿瘤防治研究2025，Vol.52Issue(5)：405-410,6.DOI:10.3971/j.issn.1000-8578.2025.24.1214
平均红细胞体积与治疗相关急性髓系白血病患者临床特征及预后的相关性分析
Correlation of Mean Corpuscular Volume with Clinical Features and Prognosis of Patients with Treatment-Related Acute Myeloid Leukemia
吕晓娴 1许青霞1
作者信息
- 1. 450008 郑州,郑州大学附属肿瘤医院(河南省肿瘤医院)检验科,郑州市消化系统肿瘤标志物重点实验室
- 折叠
摘要
Abstract
Objective To analyze the correlation of mean corpuscular volume(MCV)with clinical fea-tures and the prognosis of patients with treatment-related acute myeloid leukemia(t-AML).Methods The clinical and laboratory data of 41 patients with t-AML were retrospectively analyzed.The patients were divided into LMCV and HMCV groups.Spearman's rank correlation was used for correlation analysis,and a survival curve was drawn via Kaplan-Meier method.Log-rank test was used for comparison between groups,and Cox proportional risk regression model was used for multivariate analysis.Results The treatment history of G-CSF was positively correlated with the MCV of patients with t-AML(correlation coefficient r=0.325,P<0.05).The amount of RBC and HGB in the peripheral blood of patients and the percentage of PML-RARa positive in the LMCV group were significantly higher than those in the HMCV group,and the percentages of the expression levels of lymphoid antigen CD7 and CD56 were significantly lower than those in the HMCV group(P<0.05).The therapeutic effect,OS,and RFS of the LMCV group were better than those of the HMCV group(P<0.05).Failure to reach CR was an independent risk factor for OS of patients with t-AML(HR=0.053,P=0.002),and MCV≥98.9 fl was an adverse factor for OS and RFS of patients with t-AML(P<0.1)but not an independent risk factor(P>0.05).Conclusion Patients with t-AML with different levels of MCV have different clinical characteristics,and patients with high MCV have poor therapeutic effect and prognosis.关键词
平均红细胞体积/治疗相关急性髓系白血病/临床特点/预后Key words
Mean red blood cell volume/Treatment-related acute myeloid leukemia/Clinical characteristics/Prognosis分类
临床医学引用本文复制引用
吕晓娴,许青霞..平均红细胞体积与治疗相关急性髓系白血病患者临床特征及预后的相关性分析[J].肿瘤防治研究,2025,52(5):405-410,6.
